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首页> 外文期刊>Genetic Resources and Crop Evolution >Variability in Mucuna pruriens L. germplasm for L-Dopa, an anti parkinsonian agent
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Variability in Mucuna pruriens L. germplasm for L-Dopa, an anti parkinsonian agent

机译：抗帕金森病病原菌Mucuna pruriens L.种质对L-Dopa的变异性

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摘要

Mucuna pruriens L. (Fabaceae) is a popular Indian medicinal plant, which has long been used in traditional Ayurvedic system of Indian medicine for diseases including parkinsonism. The seeds of M. pruriens contain 3,4-dihydroxyphenyl-L-alanine (L-dopa) as a major constituent, an intermediate precursor of the neurotransmitter dopamine. L-dopa extracted from seeds of Mucuna is more effective as drug than the synthetic counterpart. The plant is widely distributed throughout the India and in other parts of the tropics including Central and South America. The present study was aimed to screen thirty-eight accessions of Mucuna germplasm collected from different geographical regions of India for L-dopa content, an effective drug used for Parkinson’s disease. The L-dopa content in seeds of M. pruriens was quantitatively analyzed by high performance thin-layer chromatography (HPTLC) at 280 nm wavelength. Results indicated wide variability among thirty-eight accessions of M. pruriens for seed characters like seed colour, size and shape. The L-dopa content in seeds of M. pruriens ranged between 3.29 and 5.44 % (on dry weight basis) among different germplasm collections augmented from various parts of India. Promising accessions identified having high L-dopa content were IC551549 (5.44 %), IC551514 (5.41 %), IC331536 (5.40 %), IC552857 (5.36 %), IC385844 (5.32 %) and IC439197 (5.32 %). Due to the economic importance of the drug, these promising M. pruriens accessions can be exploited for large scale cultivation for their pharmacological important constituents mainly L-dopa content.
机译：Mucuna pruriens L.（Fabaceae）是一种流行的印度药用植物，长期以来一直用于印度医药的传统阿育吠陀系统中，用于治疗帕金森氏病。鼠种子含有3,4-二羟基苯基-L-丙氨酸（L-多巴）作为主要成分，是神经递质多巴胺的中间前体。从Mucuna种子中提取的左旋多巴作为药物比合成对应物更有效。该植物广泛分布在整个印度以及热带的其他地区，包括中美洲和南美洲。本研究的目的是筛选从印度不同地理区域收集的38种穆卡纳种质的左旋多巴含量，这是一种用于治疗帕金森氏病的有效药物。通过高效薄层色谱法（HPTLC）在280 nm波长处定量分析了豆种子中L-多巴的含量。结果表明，在38种美洲毛of种之间，种子的性状如种子的颜色，大小和形状均存在较大差异。在印度各地增加的不同种质资源中，毛种子中的左旋多巴含量在3.29％至5.44％（以干重计）之间。鉴定出的具有高L-多巴含量的有希望的种质是IC551549（5.44％），IC551514（5.41％），IC331536（5.40％），IC552857（5.36％），IC385844（5.32％）和IC439197（5.32％）。由于该药物的经济重要性，这些有前途的M. pruriens入种可用于其主要的左旋多巴含量的药理重要成分而用于大规模种植。

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