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Nanotechnology approaches for gene transfer

机译：纳米技术的基因转移方法

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In both basic research as well as experimental gene therapy the need to transfer genetic material into a cell is of vital importance. The cellular compartment, which is the target for the genetic material, depends upon application. An siRNA that mediates silencing is preferably delivered to the cytosol while a transgene would need to end up in the nucleus for successful transcription to occur. Furthermore the ability to regulate gene expression has grown substantially since the discovery of RNA interference. In such diverse fields as medical research and agricultural pest control, the capability to alter the genetic output has been a useful tool for pushing the scientific frontiers. This review is focused on nanotechnological approaches to assemble optimised structures of nucleic acid derivatives to facilitate gene delivery as well as promoting down regulation of endogenous genes. Keywords Bioplex formation - Gene silencing - Gene therapy - LNA - Nuclear localisation signals - Oligonucleotides - PNA
机译：在基础研究和实验基因治疗中，将遗传物质转移到细胞中的需求都至关重要。细胞隔室是遗传材料的靶标，取决于应用。优选地，介导沉默的siRNA被递送至胞质溶胶，而转基因将需要终止于细胞核中以成功进行转录。此外，自从发现RNA干扰以来，调节基因表达的能力已大大提高。在医学研究和农业病虫害防治等不同领域，改变基因产量的能力一直是推动科学前沿的有用工具。这篇综述集中在组装核酸衍生物的优化结构以促进基因递送以及促进内源基因的下调的纳米技术方法上。关键词生物复合体形成-基因沉默-基因治疗-LNA-核定位信号-寡核苷酸-PNA

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