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首页> 外文期刊>Genetica >The NemaGENETAG initiative: large scale transposon insertion gene-tagging in Caenorhabditis elegans
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The NemaGENETAG initiative: large scale transposon insertion gene-tagging in Caenorhabditis elegans

机译：NemaGENETAG倡议：秀丽隐杆线虫的大规模转座子插入基因标签

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摘要

The nematode Caenorhabditis elegans is a widely appreciated, powerful platform in which to study important biological mechanisms related to human health. More than 65% of human disease genes have homologues in the C. elegans genome, and essential aspects of mammalian cell biology, neurobiology and development are faithfully recapitulated in this organism. The EU-funded NemaGENETAG project was initiated with the aim to develop cutting-edge tools and resources that will facilitate modelling of human pathologies in C. elegans, and advance our understanding of animal development and physiology. The main objective of the project involves the generation and evaluation of a large collection of transposon-tagged mutants. In the process of achieving this objective the NemaGENETAG consortium also endeavours to optimize and automate existing transposon-mediated mutagenesis methodologies based on the Mos1 transposable element, in addition to developing alternatives using other transposon systems. The final product of this initiative—a comprehensive collection of transposon-tagged alleles—together with the acquisition of efficient transposon-based tools for mutagenesis and transgenesis in C. elegans, should yield a wealth of information on gene function, immediately relevant to key biological processes and to pharmaceutical research and development. Keywords Caenorhabditis elegans - Mariner - Mos1 - Gene tagging - Tc1 - Transposon
机译：线虫秀丽隐杆线虫是一个广受赞赏的强大平台，可在其中研究与人类健康相关的重要生物学机制。超过65％的人类疾病基因在秀丽隐杆线虫基因组中具有同源物，而哺乳动物细胞生物学，神经生物学和发育的基本方面在此生物中得到了忠实的概括。由欧盟资助的NemaGENETAG项目的发起是为了开发尖端工具和资源，这些工具和资源将有助于对秀丽隐杆线虫进行人体病理建模，并加深我们对动物发育和生理学的理解。该项目的主要目标涉及大量转座子标签突变体的产生和评估。在实现这一目标的过程中，除了使用其他转座子系统开发替代方法外，NemaGENETAG联盟还努力优化和自动化基于Mos1转座因子的现有转座子介导的诱变方法。该计划的最终产品-全面收集转座子标记的等位基因-加上获得有效的基于转座子的诱变和秀丽隐杆线虫转基因工具，应产生大量与关键生物学相关的基因功能信息流程和药物研发。秀丽隐杆线虫-水手-Mos1-基因标记-Tc1-转座子

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