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Mapping quantitative trait loci for traits defined as ratios

机译:为定义为比率的性状映射定量性状基因座

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Many traits are defined as ratios of two quantitative traits. Methods of QTL mapping for regular quantitative traits are not optimal when applied to ratios due to lack of normality for traits defined as ratios. We develop a new method of QTL mapping for traits defined as ratios. The new method uses a special linear combination of the two component traits, and thus takes advantage of the normal property of the new variable. Simulation study shows that the new method can substantially increase the statistical power of QTL detection relative to the method which treats ratios as regular quantitative traits. The new method also outperforms the method that uses Box-Cox transformed ratio as the phenotype. A real example of QTL mapping for relative growth rate in soybean demonstrates that the new method can detect more QTL than existing methods of QTL mapping for traits defined as ratios.
机译:许多性状被定义为两个数量性状的比率。由于缺乏定义为比率的性状的正态性,将常规定量性状的QTL映射方法应用于比率时并非最佳。我们为定义为比率的性状开发了一种新的QTL映射方法。新方法使用了两个成分特征的特殊线性组合,因此可以利用新变量的正态性质。仿真研究表明,相对于将比率视为常规定量特征的方法,该新方法可以显着提高QTL检测的统计能力。新方法也优于使用Box-Cox转换比率作为表型的方法。一个针对大豆相对生长速率的QTL定位的真实例子表明,对于定义为比率的性状,新方法比现有的QTL定位方法可以检测到更多的QTL。

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