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首页> 外文期刊>Deutsche Zeitschrift fur Sportmedisin >Einfluß von Ausdauersport auf die Hämoxygenase-Expression peripherer Leukozyten
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Einfluß von Ausdauersport auf die Hämoxygenase-Expression peripherer Leukozyten

机译：耐力运动对外周血白细胞血氧合酶表达的影响

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Apart from the catalytic function in a variety of biotransformations, heme-oxygenase (HO-1) is an indicator of oxidative stress and a potent antioxidative enzyme. Is exercise able to affect the expression of HO-1? And furthermore, is there an effect of training on HO-1 expression at rest? Leucocytes of 12 male, trained athletes, taken 24 hours before, 0,3, and 24 hours after a half-marathon race were immediately stained and analyzed by flow-cytometry, which allowed to focus on the HO-1 expression of lymphocytes, monocytes and granulocytes separately. To compare the results with non-athlete-data, leucocytes of 12 male, untrained blood-donors were treated and analyzed in the same way. The percentage of HO-1-expressing cells rosen in all cell types examined. All cell types of the athletes showed less HO-positive cells at rest in comparison with those of the control group. As far as the white blood cells are concerned, intensive exercise increased the expression of HO-1. It is very likely that oxidative stress plays a causal role. These findings may stress the importance of heme-oxygenase in the acute defense of oxidative stress. Lower HO-percentage at rest in trained individuals could be a hint for the secondary role of heme-oxygenase in long-term adaptation. A training induced up-regulation is described for other antioxidative systems like catalase and superoxide-dismutase. This study emphasizes the importance of HO-1 as stress protein due to the acute-phase response shown above.
机译：除了在各种生物转化中的催化功能外，血红素加氧酶（HO-1）还指示氧化应激和有效的抗氧化酶。运动能影响HO-1的表达吗？而且，训练对静止的HO-1表达有影响吗？立即对半程马拉松赛前24小时，0,3和24小时后接受训练的12名男性运动员的白细胞进行染色并通过流式细胞仪进行分析，从而将重点放在淋巴细胞，单核细胞的HO-1表达上和粒细胞分别。为了将结果与非运动员数据进行比较，以相同方式处理和分析了12位未经训练的男性献血者的白细胞。在所有检查的细胞类型中，表达HO-1的细胞的百分比均上升。与对照组相比，运动员的所有细胞类型在静息时均显示较少的HO阳性细胞。就白细胞而言，剧烈运动会增加HO-1的表达。氧化应激很可能起因果作用。这些发现可能强调了血红素加氧酶在急性氧化应激防御中的重要性。训练有素的人静息时较低的HO百分比可能暗示血红素加氧酶在长期适应中的次要作用。描述了其他抗氧化系统（如过氧化氢酶和超氧化物歧化酶）的训练诱导上调。这项研究强调了由于上述急性期反应，HO-1作为应激蛋白的重要性。

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