Granular dynamics simulations of the effect of grain size dispersity on uniaxially compacted powder blends

Meenakshi Dutt; James A. Elliott

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Granular dynamics simulations of the effect of grain size dispersity on uniaxially compacted powder blends

机译：粒度分布对单轴压实粉末共混物影响的颗粒动力学模拟

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摘要

We investigate, via granular dynamics simulations, the influence of particle size dispersity on the packing characteristics of uniaxially compacted pharmaceutical blends. We employ reduced models of representative pharmaceutical excipient blends comprised of one, two, four and six components of different size, where the grain size in each component is distinct. We investigate the particle dynamics and reorganization during the compaction phase after the blend has been poured into a tablet die. For small strains, we demonstrate the packing fraction of the powder blends to scale linearly with the axial strain. We do not observe any significant variation in the stress response of the blend with particle size dispersity at small strains, but the mixtures with greater particle size dispersity remain compactible up to higher strains than the less polydisperse mixtures.

机译：我们通过颗粒动力学模拟研究了粒径分散度对单轴压实药物混合物的包装特性的影响。我们采用代表性的药物赋形剂共混物的简化模型，该共混物共混物由大小不同的一种，两种，四种和六种成分组成，其中每种成分的颗粒大小均不同。我们研究了将共混物倒入片剂后的压实阶段的颗粒动力学和重组过程。对于小应变，我们证明了粉末混合物的填充分数与轴向应变成线性比例。我们在小应变下没有观察到随粒径分布的共混物的应力响应的任何显着变化，但与较低多分散性的混合物相比，具有较大粒径分散性的混合物在较高应变下仍可压实。

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来源
《Granular matter》 |2014年第2期|243-248|共6页
作者
Meenakshi Dutt; James A. Elliott;
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作者单位

Department of Chemical and Biochemical Engineering, Rutgers The State University of New Jersey, Piscataway, NJ 08854, USA;

Department of Materials Science and Metallurgy, University of Cambridge, 27 Charles Babbage Road, Cambridge CB3 OFS, UK;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);
原文格式 PDF
正文语种 eng
中图分类
关键词
Discrete element modeling; Size dispersity; Particle packing;

机译：离散元素建模;尺寸分散;颗粒堆积;

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Granular dynamics simulations of the effect of grain size dispersity on uniaxially compacted powder blends

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