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Numerical simulation of free flowing particles mixing in V-blender

机译:V型混合器混合的自由流动粒子的数值模拟

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摘要

The aim of this study is to present a novel approach for analyzing the pharmaceutical solid mixing performance of monodisperse particles by a numerical simulation using the mathematical model of rigid solid objects for a large span of time reached 20min. In order to ensure the viability of a numerical simulation, an experimental study of a binary mixture of monodisperse particles considered as free flowing material (18mm in diameter) in pharmaceutical V blender, was developed. The effect of the process parameters on the mixing performance such as the rotational speed (10 and 27 tr/min), the filling level of the vessel (35 and 75%), and the percentage of the tracer (10 and 50%) for three loading profiles (FB: front back, RL: right left, TB: top, bottom) was evaluated. The experimental results were discussed and compared to the numerical simulation ones, in terms of relative standard deviation presentations, and the arrangement of the particles in the vessel. A good agreement was obtained for all experimental conditions, even for the RL loading profile, which shows difficulties in simulations using other simulation methods. By using this model the pharmaceutical mixing process can be simulated for a large mixing time.
机译:该研究的目的是提出一种新的方法,用于通过使用刚性固体物体的数学模型进行数值模拟来分析单分散颗粒的药物固体混合性能,以便大跨度达到20分钟。为了确保数值模拟的可行性,开发了在药物v搅拌器中被认为是自由流动材料(直径18mm)的单分散颗粒的二元混合物的实验研究。工艺参数对混合性能的影响,例如转速(10和27 Tr / min),容器的填充水平(35和75%),以及示踪剂(10和50%)的百分比评估了三个装载配置文件(FB:前后,RL:右左,TB:顶部,底部)。讨论了实验结果,并与数值模拟介绍的结果进行了比较,以及容器中颗粒的布置。对于所有实验条件,也可以获得良好的一致性,即使是RL加载轮廓,也可以使用其他模拟方法显示模拟中的困难。通过使用该模型,可以模拟药物混合过程以进行大混合时间。

著录项

  • 来源
    《Granular matter》 |2019年第2期|35.1-35.14|共14页
  • 作者单位

    Univ Sci & Technol Houari Boumediene Fac Mech Engn & Proc Engn Lab Transfer Phenomenon BP32 El Alia Bab Ezzouar Algiers 16111 Algeria;

    Univ Sci & Technol Houari Boumediene Fac Mech Engn & Proc Engn Lab Sci & Engn Mat BP32 El Alia Bab Ezzouar Algiers 16111 Algeria;

    Univ Sci & Technol Houari Boumediene Fac Mech Engn & Proc Engn Lab Transfer Phenomenon BP32 El Alia Bab Ezzouar Algiers 16111 Algeria;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);
  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    Numerical simulation; Solid rigid model; Mixing; Free flowing material; Particles; V-blender;

    机译:数值模拟;固体刚性模型;混合;自由流动材料;颗粒;V-搅拌器;

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