...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Growth, Development, & Aging >Catch-Up in Body Weight of Intrauterine Growth Retarded (IUGR) Rats Castrated and Treated with Growth Hormone
【24h】

Catch-Up in Body Weight of Intrauterine Growth Retarded (IUGR) Rats Castrated and Treated with Growth Hormone

机译：Hor割并用生长激素治疗宫内生长迟缓（IUGR）大鼠的体重

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The aim of the present study was to assess body weight recovery in rats with intrauterine growth retardation (IUGR) castrated and treated with growth hormone (GH). Wistar albino rats were divided into the following experimental groups: control (C), sham-operated (SH), IUGR, IUGR castrated (IUGR+C), and IUGR castrated and injected with GH (IUGR+C+GH). IUGR was induced by partial bending of uterine vessels at day 14 of pregnancy. GH (Genotropin® 3.0 mg/kg/day) was administered from weaning (21 days old) to 60 days of age. SH rats were injected only with diluent. Castration was performed at weaning. Body weight, body weight velocity and relative food intake were regis- tered weekly. Data were analyzed by ANOVA and LSD post hoc test. The between-subjects analysis showed significant differences for sex and treatment factors. Differences in body weight were significant among treatments, being SH > IUGR > IUGR+ C+GH > IUGR+C in males, and SH > IUGR+C > IUGR+C+GH > IUGR in females. Differences in relative food intake were IUGR+C > IUGR+C+GH > IUGR > SH in males, and IUGR+C+GH > IUGR+C > IUGR > SH in females. These results indicate that nutritional rehabilitation impairs the effects of IUGR. While the absence of testosterone inhibited body weight gain, the absence of estrogens promoted catch-up growth. Castrated animals with or without GH treatment ate relatively more, suggesting the absence of an anabolic effect of gonadal steroids.
机译：本研究的目的是评估uter割并用生长激素（GH）治疗的宫内发育迟缓（IUGR）大鼠的体重恢复。 Wistar白化病大鼠分为以下实验组：对照组（C），假手术（SH），IUGR，cast割的IUGR（IUGR + C）和cast割的IUGR并注射GH（IUGR + C + GH）。 IUGR是在妊娠第14天时子宫血管部分弯曲引起的。从断奶（21天大）至60天大时服用GH（3.0 mg / kg /天）。 SH大鼠仅注射稀释剂。断奶时进行割。每周记录体重，体重速度和相对食物摄入量。通过ANOVA和LSD事后检验分析数据。受试者间分析显示性别和治疗因素存在显着差异。在治疗之间，体重差异显着，男性为SH> IUGR> IUGR + C + GH> IUGR + C，女性为SH> IUGR + C> IUGR + C + GH> IUGR。男性的相对食物摄入量差异为IUGR + C> IUGR + C + GH> IUGR> SH，女性为IUGR + C + GH> IUGR + C> IUGR> SH。这些结果表明，营养康复会损害IUGR的作用。缺乏睾丸激素可抑制体重增加，而缺乏雌激素则可促进追赶性生长。接受或不接受GH治疗的割动物进食的相对较多，表明缺乏性腺类固醇的合成代谢作用。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号