Gene expression patterns in peripheral blood leukocytes in patients with recurrent ciguatera fish poisoning: Preliminary studies

Lopez Maria-Cecilia; Ungaro Ricardo F.; Baker Henry V.; Moldawer Lyle L.; Robertson Alison; Abbott Margaret; Roberts Sparkle M.; Grattan Lynn M.; Morris J. Glenn Jr.

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Gene expression patterns in peripheral blood leukocytes in patients with recurrent ciguatera fish poisoning: Preliminary studies

机译：复发性卡加拉塔鱼中毒患者外周血白细胞基因表达模式的初步研究

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Ciguatera fish poisoning (ciguatera) is a common clinical syndrome in areas where there is dependence on tropical reef fish for food. A subset of patients develops recurrent and, in some instances, chronic symptoms, which may result in substantial disability. To identify possible biomarkers for recurrent/chronic disease, and to explore correlations with immune gene expression, peripheral blood leukocyte gene expression in 10 ciguatera patients (7 recurrent and 3 acute) from the U.S. Virgin Islands, and 5 unexposed Florida controls were evaluated. Significant differences in gene expression were noted when comparing ciguatera patients and controls; however, it was not possible to differentiate between patients with acute and recurrent disease, possibly due to the small sample sizes involved. (C) 2016 Elsevier B.V. All rights reserved.

机译：Ciguatera鱼中毒（ciguatera）是在依赖热带礁鱼作为食物的地区常见的临床综合征。一小部分患者会复发，在某些情况下会出现慢性症状，这可能会导致严重的残疾。为确定复发/慢性疾病的可能生物标志物，并探讨与免疫基因表达的相关性，评估了来自美属维尔京群岛的10例美洲豹患者（7例复发和3例急性患者）和5例未暴露的佛罗里达对照组的外周血白细胞基因表达。比较雪茄患者和对照组时，注意到基因表达的显着差异。但是，由于所涉及的样本量较小，因此无法区分急性和复发性疾病患者。（C）2016 Elsevier B.V.保留所有权利。

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来源
《Harmful Algae》 |2016年第ptab期|35-38|共4页
作者
Lopez Maria-Cecilia; Ungaro Ricardo F.; Baker Henry V.; Moldawer Lyle L.; Robertson Alison; Abbott Margaret; Roberts Sparkle M.; Grattan Lynn M.; Morris J. Glenn Jr.;
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作者单位

Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA;

Univ Florida, Coll Med, Dept Surg, Gainesville, FL 32610 USA;

Univ Florida, Coll Med, Dept Mol Genet & Microbiol, Gainesville, FL 32610 USA|Univ Florida, Coll Med, Dept Surg, Gainesville, FL 32610 USA|Univ Florida, Genet Inst, Gainesville, FL 32610 USA;

Univ Florida, Coll Med, Dept Surg, Gainesville, FL 32610 USA;

Univ S Alabama, Dept Marine Sci, Marine Ecotoxicol Lab, Mobile, AL 36688 USA|Dauphin Island Sea Lab, Dauphin Isl, AL USA;

Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32610 USA;

Univ Maryland, Sch Med, Div Neuropsychol, Dept Neurol, 110 S,Paca St,3rd Floor, Baltimore, MD 21201 USA;

Univ Maryland, Sch Med, Div Neuropsychol, Dept Neurol, 110 S,Paca St,3rd Floor, Baltimore, MD 21201 USA;

Univ Florida, Emerging Pathogens Inst, Gainesville, FL 32610 USA|Univ Florida, Emerging Pathogens Inst, Coll Med, Dept Med, 2055 Mowry Rd,Box 100009, Gainesville, FL 32610 USA;

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正文语种 eng
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关键词
Ciguatera; Gene expression; US Virgin Islands; Fish poisoning;

机译：Ciguatera;基因表达;美属维尔京群岛;鱼中毒;

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1. Analysis of Significance Patterns Identifies Ubiquitous and Disease-Specific Gene-Expression Signatures in Patient Peripheral Blood Leukocytes [J] . DAMIEN CHAUSSABEL, WINDY ALLMAN, ASUNCION MEJIAS, Annals of the New York Academy of Sciences . 2005,第Dec期

机译：有效模式分析确定患者外周血白细胞中普遍存在的和特定疾病的基因表达特征
2. Altered Gene Expression Pattern in Peripheral Blood Leukocytes from Patients with Arterial Hypertension [J] . A.Y TIMOFEEVA, L.E. GORYUNOVA, G.L. KHASPEKOV, Annals of the New York Academy of Sciences . 2006,第Dec期

机译：高血压患者外周血白细胞基因表达模式的改变
3. Dynamic gene expressions of peripheral blood mononuclear cells in patients with acute exacerbation of chronic obstructive pulmonary disease: a preliminary study [J] . Xiaodan Wu, Xiaoru Sun, Chengshui Chen, Critical care : . 2014,第6期

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4. Peripheral blood serial gene expression profiling in the follow up of intestinal transplant patients: preliminary results [C] . Ruiz P., Tryphonopoulos P., Weppler D., International Small Bowel Transplant Symposium . 2009

机译：外周血串行基因表达探讨在肠道移植患者的后续型：初步结果
5. Grazing Dynamics of the Pinfish (Lagodon rhomboides) on Thalassia testudinum and Halimeda incrassata across a Temperature Gradient in the Florida Keys and Implications for Ciguatera Fish Poisoning [D] . Ribble, Kathryn Alissa. 2019

机译：在佛罗里达群岛群中的温度梯度上放牧皮鱼（Lagodon rhomboides）的动力学和Halimeda Incassata在佛罗里达群体的温度梯度和Ciguatera鱼类中毒的影响
6. Gene Expression Patterns in Peripheral Blood Leukocytes in Patients with Recurrent Ciguatera Fish Poisoning: Preliminary Studies [O] . Maria-Cecilia Lopez, Ricardo F. Ungaro, Henry V. Baker, -1

机译：复发性瓜鱼中毒患者外周血白细胞基因表达模式的初步研究
7. Gene expression patterns in peripheral blood leukocytes in patients with recurrent ciguatera fish poisoning: Preliminary studies [O] . Department of Molecular Genetics and Microbiology, College of Medicine, University of Florida, Gainesville, FL 32610, USA ( host institution ), Lopez, Maria-Cecilia ( UF author ), Ungaro, Ricardo F. ( UF author ), 2016

机译：复发性卡加拉塔鱼中毒患者外周血白细胞基因表达模式的初步研究

Gene expression patterns in peripheral blood leukocytes in patients with recurrent ciguatera fish poisoning: Preliminary studies

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