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首页> 外文期刊>Harmful Algae >Toxicity studies of Trichodesmium erythraeum (Ehrenberg, 1830) bloom extracts, from Phoenix Bay, Port Blair, Andamans
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Toxicity studies of Trichodesmium erythraeum (Ehrenberg, 1830) bloom extracts, from Phoenix Bay, Port Blair, Andamans

机译：来自安达曼斯州布莱尔港凤凰湾的红毛毛滴虫（Ehrenberg，1830年）花朵提取物的毒性研究

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摘要

Occurrence of toxic cyanobacterial blooms has become a worldwide problem, increasing the risk of human poisoning due to consumption of seafood contaminated with cyanotoxins. Though no such cases of human intoxication due to toxic blooms have been reported so far from India, most of the studies related to blooms have been restricted to reporting of a bloom and/or antimicrobial activity of its extract. Detailed toxicity study of cyanobacterial blooms are lacking. A study on the toxicity of a dense bloom (14.56 × 10~6trichomes L~(-1)) of the marine diazotrophic cyanobacteria, Trichodesmium erythraeum, observed in the coastal waters of Phoenix Bay, Port Blair, Andamans was undertaken. The significance of this bloom is that it was a single species and had conspicuously inhibited the growth of other phytoplankton and complete exclusion of zooplankton from the bloom region, intimating the involvement of toxins in the bloom. The cyanobacterial extracts showed prominent antimicrobial activity against certain human pathogenic bacteria and fungi. Studies on the toxicity of the cyanobacterial extracts was carried out using brine shrimp bioassay, 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and comet assay. The cyanobacterial extract exhibited toxic effect to Anemia salina causing mortality of up to 40% after 48 h at a concentration of 1 mg mL~(-1), while it induced cytotoxicity in cell lines (HepG2 and HaCat) and caused DNA damage in human lymphocytes in vitro.
机译：有毒的蓝藻水华的发生已成为世界性问题，由于食用被蓝藻毒素污染的海鲜，增加了中毒的风险。尽管到目前为止，从印度至今尚无因有毒的花开而引起人中毒的案例，但大多数与花开有关的研究仅限于报道其提取物的花开和/或抗菌活性。缺乏对蓝藻水华的详细毒性研究。研究了在安达曼斯州布莱尔港凤凰湾沿岸海域发现的重氮营养蓝细菌密集红藻（Trichodesmium erythraeum）（14.56×10〜6trichomes L〜（-1））的毒性。绽放的意义在于它是一个物种，并且显着地抑制了其他浮游植物的生长，并将浮游动物完全排除在绽放区域之外，从而刺激了毒素在绽放中的参与。蓝细菌提取物对某些人类致病细菌和真菌具有显着的抗菌活性。使用盐水虾生物测定，3-（4,5-二甲基噻唑-2-基）-2,5-二苯基四唑溴化物（MTT）测定和彗星测定进行了蓝藻提取物毒性的研究。蓝藻提取物对贫血盐沼具有毒性作用，在浓度为1 mg mL〜（-1）的情况下，在48 h后可导致高达40％的死亡率，同时在细胞系（HepG2和HaCat）中诱导细胞毒性并导致人类DNA损伤体外淋巴细胞。

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  • 来源
    《Harmful Algae》 |2014年第12期|34-39|共6页
  • 作者

    Sumantha Narayana; J. Chitra; Savita R. Tapase; Viresh Thamke; P. Karthick; Ch. Ramesh; Kada Narayana Murthy; M. Ramasamy; Kisan M. Kodam; R. Mohanraju;

  • 作者单位

    Department of Ocean Studies and Marine Biology, Pondicherry University, Brookshabad Campus, Port Blair 744112, Andaman & Nicobar Is., India;

    AU-KBC Research Centre, MIT Campus of Anna University, Chennai 600044, India;

    Biochemistry Division, Department of Chemistry, Savitribai Phule Pune University, Pune 411007, India;

    Biochemistry Division, Department of Chemistry, Savitribai Phule Pune University, Pune 411007, India;

    Department of Ocean Studies and Marine Biology, Pondicherry University, Brookshabad Campus, Port Blair 744112, Andaman & Nicobar Is., India;

    Department of Ocean Studies and Marine Biology, Pondicherry University, Brookshabad Campus, Port Blair 744112, Andaman & Nicobar Is., India;

    Department of Ocean Studies and Marine Biology, Pondicherry University, Brookshabad Campus, Port Blair 744112, Andaman & Nicobar Is., India;

    AU-KBC Research Centre, MIT Campus of Anna University, Chennai 600044, India;

    Biochemistry Division, Department of Chemistry, Savitribai Phule Pune University, Pune 411007, India;

    Department of Ocean Studies and Marine Biology, Pondicherry University, Brookshabad Campus, Port Blair 744112, Andaman & Nicobar Is., India;

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  • 正文语种 eng
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  • 关键词

    Cyanobacteria bloom; Trichodesmium erythraeum; MTT assay; Comet assay;

    机译：蓝细菌开花;红细菌毛滴虫;MTT分析;彗星测定;

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