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首页> 外文期刊>Harmful Algae >Red tide dinoflagellate Cochlodinium polykrikoides induces significant oxidative stress and DNA damage in the gill tissue of the red seabream Pagrus major
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Red tide dinoflagellate Cochlodinium polykrikoides induces significant oxidative stress and DNA damage in the gill tissue of the red seabream Pagrus major

机译：赤潮鞭毛甲壳虫中的多鞭毛虫会在大红鲷的major组织中诱导明显的氧化应激和DNA损伤

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摘要

The ichthyotoxic Cochlodinium polykrikoides is one of the most harmful bloom-forming dinoflagellates. In the present study, the economically important red seabream Pagrus major was exposed to sublethal concentrations of C. polykrikoides (i.e., 1,000 and 3,000 cells mL(-1)) for 24 h, and the antioxidant defense system and DNA damage dose-specific responses were analyzed during the exposure and additional depuration period (2 h) in the gill tissue. No significant ichthyotoxicity was observed under different light and dark conditions, while significantly lower levels of opercular respiratory rate were measured in the C. polykrikoides-exposed red seabream. Intracellular malondialdehyde (MDA) content increased significantly in the 3,000 cells-exposed gill tissues at 24 h and the increased level was maintained during depuration. Intracellular glutathione (GSH) levels were significantly depleted following exposure to 3,000 cells mL(-1) of C. polykrikoides, but the levels increased significantly in the depuration phase. Overall, significantly higher activity of antioxidant defense system enzymes such as catalase (CAT), superoxide dismutase (SOD), glutathione reductase (GR), and glutathione peroxidase (GPx) were observed in the 3,000 cells mL(-1)-exposed gill tissues at 24 h and during depuration. Analysis of the two reliable DNA damage parameters, Olive tail moment and percent tail DNA, showed significantly elevated levels of DNA damage in the 1,000 and 3,000 cells mL(-1)-exposed gill tissue. Increases in the activity of the antioxidant defense system and DNA damage may be one of the major mechanisms mediating C. polykrikoides-induced devastation in aquaculture and fisheries.
机译：具有鱼腥毒素的Cochlodinium polykrikoides是最有害的形成花白藻的鞭毛藻之一。在本研究中，具有经济意义的红鲷Pagrus major暴露于致死浓度为C. polykrikoides（即1,000和3,000细胞mL（-1））达24小时，并且抗氧化剂防御系统和DNA损伤剂量特异性反应在暴露和and组织的额外净化期（2小时）中进行了分析。在不同的光照和黑暗条件下均未观察到明显的鱼鳞毒素，而暴露于多角形衣原体的红鲷鱼的呼吸呼吸速率显着降低。在24 h，暴露于3,000个细胞的g组织中的细胞内丙二醛（MDA）含量显着增加，并且在净化过程中保持了升高的水平。暴露于3,000个细胞mL（-1）的多角梭菌后，细胞内谷胱甘肽（GSH）的水平显着减少，但在净化阶段该水平显着增加。总体而言，在暴露于3,000个细胞mL（-1）的g组织中观察到抗氧化防御系统酶（例如过氧化氢酶（CAT），超氧化物歧化酶（SOD），谷胱甘肽还原酶（GR）和谷胱甘肽过氧化物酶（GPx））的活性明显更高。在24小时内和净化期间。分析两个可靠的DNA损伤参数，Olive尾矩和尾巴DNA百分比，表明暴露于1,000和3,000细胞mL（-1）的g组织中DNA损伤的水平显着升高。抗氧化剂防御系统活性的提高和DNA的破坏可能是介导多角线虫对水产养殖和渔业造成破坏的主要机制之一。

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  • 来源
    《Harmful Algae》 |2019年第6期|37-45|共9页
  • 作者

    Shin Yun Kyung; Nam Sang-Eun; Kim Won Jin; Seo Do Yeon; Kim Youn-Jung; Rhee Jae-Sung;

  • 作者单位

    Natl Inst Fisheries Sci Southeast Sea Fisheries Res Inst Tongyeong 39768 South Korea;

    Incheon Natl Univ Coll Nat Sci Dept Marine Sci Incheon 22012 South Korea;

    Incheon Natl Univ Coll Nat Sci Dept Marine Sci Incheon 22012 South Korea|Incheon Natl Univ Res Inst Basic Sci Incheon 22012 South Korea;

    Incheon Natl Univ Coll Nat Sci Dept Marine Sci Incheon 22012 South Korea|Incheon Natl Univ Res Inst Basic Sci Incheon 22012 South Korea|Inst Green Environm Res Ctr 169 Gaetbeol Ro Incheon 21999 South Korea;

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  • 正文语种 eng
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  • 关键词

    Cochlodinium polykrikoides; Red tide; Red seabream; Oxidative stress; DNA damage;

    机译：Cochlodinium polykrikoides;赤潮;红鲷鱼;氧化应激DNA损伤;

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