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首页> 外文期刊>Heart >Long chain n-3 polyunsaturated fatty acids and incidence rate of coronary artery calcification in Japanese men in Japan and white men in the USA: population based prospective cohort study
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Long chain n-3 polyunsaturated fatty acids and incidence rate of coronary artery calcification in Japanese men in Japan and white men in the USA: population based prospective cohort study

机译：日本日本男性和美国白人中长链n-3多不饱和脂肪酸与冠状动脉钙化的发生率：基于人群的前瞻性队列研究

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摘要

Objective To determine whether serum concentrations of long chain n-3 polyunsaturated fatty acids (LCn3PUFAs) contribute to the difference in the incidence rate of coronary artery calcification (CAC) between Japanese men in Japan and white men in the USA. Methods In a population based, prospective cohort study, 214 Japanese men and 152 white men aged 40-49 years at baseline (2002-2006) with coronary calcium score (CCS)=0 were re-examined for CAC in 2007-2010. Among these, 175 Japanese men and 113 white men participated in the follow-up exam. Incident cases were defined as participants with CCS≥10 at follow-up. A relative risk regression analysis was used to model the incidence rate ratio between the Japanese and white men. The incidence rate ratio was first adjusted for potential confounders at baseline and then further adjusted for serum LCn3PUFAs at baseline. Results Mean (SD) serum percentage of LCn3PUFA was ＞100% higher in Japanese men than in white men (9.08 (2.49) vs 3.84 (1.79), respectively, p＜0.01). Japanese men had a significantly lower incidence rate of CAC compared to white men (0.9 vs 2.9/100 person-years, respectively, p＜0.01). The incidence rate ratio of CAC taking follow-up time into account between Japanese and white men was 0.321 (95% Cl 0.150 to 0.690; p＜0.01). After adjusting for age, systolic blood pressure, low density lipoprotein cholesterol, diabetes, and other potential confounders, the ratio remained significant (0.262, 95% Cl 0.094 to 0.731; p=0.01). After further adjusting for LCn3PUFAs, however, the ratio was attenuated and became non-significant (0.376, 95% Cl 0.090 to 1.572; p=0.18). Conclusions LCn3PUFAs significantly contributed to the difference in the incidence of CAC between Japanese and white men.
机译：目的确定长链n-3多不饱和脂肪酸（LCn3PUFAs）的血清浓度是否有助于日本日本男性和美国白人之间冠状动脉钙化（CAC）发生率的差异。方法在一项基于人群的前瞻性队列研究中，对2007年至2010年基线时（2002-2006年）冠心钙评分（CCS）= 0的214名日本男性和152名白人男性（年龄在40-49岁之间）进行了重新检查。其中，有175名日本男子和113名白人男子参加了后续考试。事故病例定义为随访时CCS≥10的参与者。使用相对风险回归分析来模拟日本男子和白人男子之间的发病率比率。首先在基线时针对潜在混杂因素调整发病率比率，然后在基线时进一步针对血清LCn3PUFA进行调整。结果日本男性LCn3PUFA的平均（SD）血清百分比比白人男性高＞ 100％（分别为9.08（2.49）和3.84（1.79），p ＜0.01）。日本男性的CAC发病率明显低于白人男性（分别为0.9和2.9 / 100人年，p ＜0.01）。考虑到随访时间，日本和白人男性之间的CAC发生率为0.321（95％Cl为0.150至0.690； p ＜0.01）。在调整了年龄，收缩压，低密度脂蛋白胆固醇，糖尿病和其他潜在混杂因素之后，该比例仍然很显着（0.262，95％Cl 0.094至0.731； p = 0.01）。然而，在进一步调整LCn3PUFAs之后，该比例减弱并且变得不显着（0.376，95％Cl 0.090至1.572； p ＝ 0.18）。结论LCn3PUFAs显着促进了日本男子和白人男子CAC发病率的差异。

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  • 来源
    《Heart》 |2014年第7期|569-573|共5页
  • 作者

    Akira Sekikawa; Katsuyuki Miura; Sunghee Lee; Akira Fujiyoshi; Daniel Edmundowicz; Takashi Kadowaki; Rhobert W Evans; Sayaka Kadowaki; Kim Sutton-Tyrrell; Tomonori Okamura; Mamie Bertolet; Kamal H Masaki; Yasuyuki Nakamura; Emma J M Barinas-Mitchell; Bradley J Willcox; Aya Kadota; Todd B Seto; Hiroshi Maegawa; Lewis H Kuller; Hirotsugu Ueshima;

  • 作者单位

    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA,Graduate School of Public Health, University of Pittsburgh, 130 North Bellefield Avenue, Suite 546, Pittsburgh, PA 15213, USA;

    Department of Health Science, Shiga University of Medical Science, Otsu, Shiga, Japan;

    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;

    Department of Health Science, Shiga University of Medical Science, Otsu, Shiga, Japan;

    Department of Medicine, Temple University, Philadelphia, Pennsylvania, USA,Heart and Vascular Institute, University of Pittsburgh Medical Center, Pittsburgh, Pennsylvania, USA;

    Department of Health Science, Shiga University of Medical Science, Otsu, Shiga, Japan;

    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;

    Department of Health Science, Shiga University of Medical Science, Otsu, Shiga, Japan;

    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;

    Department of Health Science, Shiga University of Medical Science, Otsu, Shiga, Japan,Department of Preventive Medicine and Public Health, Keio University, Tokyo, Japan;

    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;

    Department of Geriatric Medicine, University of Hawaii, Honolulu, Hawaii, USA;

    Department of Cardiovascular Epidemiology, Kyoto Women's University, Kyoto, Japan;

    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;

    Department of Geriatric Medicine, University of Hawaii, Honolulu, Hawaii, USA;

    Department of Health Science, Shiga University of Medical Science, Otsu, Shiga, Japan,Osaka Kyoiku University, Kashiwara, Osaka, Japan;

    Internal Medicine & Cardiology, Queen's Hospital, Honolulu, Hawaii, USA;

    Department of Medicine, Shiga University of Medical Science, Otsu, Shiga, Japan;

    Department of Epidemiology, University of Pittsburgh, Pittsburgh, Pennsylvania, USA;

    Department of Health Science, Shiga University of Medical Science, Otsu, Shiga, Japan;

  • 收录信息 美国《科学引文索引》(SCI);美国《化学文摘》(CA);
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