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Inverse Photoacoustic Technique for Parameter and Temperature Estimation in Tissues

机译：逆光声技术用于组织参数和温度估计

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摘要

The knowledge of tissues' properties and the noninvase monitoring of internal temperature are required in novel medical diagnostic and therapeutic techniques. For example, in the hyperthermia therapy of cancer, local heating must be accurately controlled in order to promote necrosis of the cancerous cells in thermoablation, or to induce apoptosis as an adjuvant treatment to chemotherapy or radiotherapy, without thermally affecting healthy cells. Photoacoustic imaging, also called optoacoustic imaging, is a new biomedical technique based on laser-generated ultrasound, which combines the high contrast of optical imaging with the high spatial resolution of ultrasound. Since parameters appearing in the mathematical formulation of the photoacoustic problem are temperature dependent, their estimation can be used as indirect temperature measurement. In the present work, sound speed, absorption coefficient, and a parameter that includes thermal expansion coefficient, laser energy density, and specific heat, are estimated through inverse analysis aiming at the identification of the tissue temperature. The forward problem is solved analytically using Laplace's transform, while the inverse problem is solved with a Markov chain Monte Carlo method within the Bayesian framework. Results obtained with simulated measurements reveal the capabilities of the proposed technique of parameter and temperature estimation.
机译：在新颖的医学诊断和治疗技术中，需要了解组织的性质以及对内部温度进行非侵入式监测。例如，在癌症的高温疗法中，必须精确控制局部加热，以促进热消融过程中癌细胞的坏死，或诱导细胞凋亡作为化学疗法或放射疗法的辅助疗法，而不会对健康细胞产生热影响。光声成像，也称为光声成像，是一种基于激光产生的超声的新生物医学技术，该技术将光学成像的高对比度与超声的高空间分辨率结合在一起。由于出现在光声问题数学公式中的参数与温度有关，因此可以将它们的估计值用作间接温度测量。在目前的工作中，针对组织温度的识别，通过反分析来估算声速，吸收系数以及包括热膨胀系数，激光能量密度和比热在内的参数。前向问题使用拉普拉斯变换进行分析求解，而反问题通过贝叶斯框架内的马尔可夫链蒙特卡罗方法求解。通过模拟测量获得的结果揭示了所提出的参数和温度估算技术的功能。

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  • 来源
    《Heat Transfer Engineering》 |2017年第18期|1573-1594|共22页
  • 作者

    Mohsen Alaeian; Helcio Rangel Barreto Orlande;

  • 作者单位

    Department of Mechanical Engineering, Federal University of Rio de Janeiro, Brazil;

    Department of Mechanical Engineering, Federal University of Rio de Janeiro, Brazil;

  • 收录信息 美国《科学引文索引》(SCI);美国《工程索引》(EI);美国《生物学医学文摘》(MEDLINE);
  • 原文格式 PDF
  • 正文语种 eng
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