Cardiac Acclimatization at High Altitude in Two Different Ethnicity Groups

Gaur Priya; Sartmyrzaeva Meerim; Maripov Abdirashit; Uulu Kubatbek Muratali; Saini Supriya; Ray Koushik; Kishore Krishna; Akunov Almaz; Sarybaev Akpay; Kumar Bhuvnesh; Singh Shashi Bala; Vats Praveen

摘要

Gaur, Priya, Meerim Sartmyrzaeva, Abdirashit Maripov, Kubatbek Muratali Uulu, Supriya Saini, Koushik Ray, Krishna Kishore, Almaz Akunov, Akpay Sarybaev, Bhuvnesh Kumar, Shashi Bala Singh, and Praveen Vats. Cardiac acclimatization at high altitude in two different ethnicity groups. High Alt Med Biol. 22:58-69, 2021.Introduction: High altitude (HA) exposure causes substantial increase in pulmonary artery pressure (PAP) and resistance. However, the effects of HA hypoxia exposure on cardiac function remain incompletely understood. Studies evaluating interethnic differences in cardiac functions in response to HA exposure are lacking. We aimed to compare the cardiac performance in Indian versus Kyrgyz healthy lowland subjects over the course of a 3-week HA exposure at 4,111 m.Methodology: Ten Indians and 20 Kyrgyz subjects were studied to assess cardiac acclimatization noninvasively by echocardiography in two different ethnic groups for 3 weeks of stay at HA. Pulmonary hemodynamics, right and left ventricular functions were evaluated at basal and on days 3, 7, 14, and 21 of HA exposure and on day 3 of deinduction.Results: HA exposure significantly increased PAP, pulmonary vascular resistance, cardiac output (CO), and heart rates (HRs) in both groups. Tricuspid regurgitant gradient increased significantly in both the group at day 3 versus basal; 38.9 mmHg (31.8, 42.9) versus 21.9 mmHg (19.5, 22.6) in Kyrgyz; and 34.1 mmHg (30.2, 38.5) versus 20.4 mmHg (19.7, 21.3) in Indians. HR increased significantly in Indians at day 3 and 7, whereas in Kyrgyz throughout exposure. CO increased significantly in both groups at day 3 versus basal with 5.9 L/min (5.5, 6.4) versus 5.1 L/min (4.4, 5.9) in Kyrgyz, and 5.7 L/min (5.56, 5.98) versus 4.9 L/min (4.1, 5.3) in Indians. Both groups exhibited preserved right ventricular diastolic and systolic functions at HAs. HA exposure changed the left ventricular diastolic parameters only in Kyrgyz subjects with impaired mitral inflow E/A, but not in Indian subjects. All cardiac changes induced at HAs have been recovered fully upon deinduction in both, except lateral-septal A ', which remained low in Indians.Conclusion: Although pulmonary hemodynamics responses were similar in both groups, there were differences in cardiac functional parameters between the two in response to HA exposure that may be accounted to ethnic variation.

机译：Gaur，Priya，Meerim Sartmyrzaeva，Abdirashit Maripov，Kubatbek Muratali Uulu，Supriya Saini，Koushik Ray，Krishna Kishore，Almaz Akunov，Akpay Sarybaev，Bhuvnesh Kumar，Shashi Bala Singh，以及前往VATS。两种不同种族群体高海拔心脏适应性化。高Alt Med Biol。 22：58-69,2021.详细信息：高海拔（HA）暴露导致肺动脉压（PAP）和抗性的大量增加。然而，HA缺氧暴露对心脏功能的影响仍然不完全理解。缺乏研究心脏功能的整体差异的研究缺乏。我们的目标是在4,111 M.m.methodology的3周暴露过程中比较印度对吉尔吉斯健康的低地受试者的心脏表现：研究了十个印第安人和20名吉尔吉斯学科，通过两种不同的民族的超声心动图来评估心脏依赖性非侵入性。哈哈休息3周。在基础和第3,7,14和21天的HA暴露和DIDINCUCTION第3天进行评估肺血流动力学，右心室功能。结果：HA暴露显着增加了PAP，肺血管阻力，心输出（CO）和两组中的心率（HRS）。 Tricuspid反rgitantant梯度在第3天与基础上的组中显着增加; 38.9 mmhg（31.8,42.9）与吉尔吉斯的21.9 mmhg（19.5,22.6）;印度人的34.1毫米（30.2,38.5）与20.4 mmhg（19.7,21.3）。在第3天和第7天，人力资源在印度人中显着增加，而在吉尔吉斯整个曝光中。 CO在两组的第3天与基底（5.5,6.4）而在吉尔吉斯中的5.1升/分钟（4.4,5.9），5.7升/分钟（5.56,5.98）与4.9升/分钟（ 4.1,5.3）在印第安人。两组均具有保存的右心室舒张和收缩功能。 HA暴露仅在吉尔吉斯患者中改变了左心室舒张分的参数，其中二尖瓣流入E / A受损，但不在印度受试者中。除了在印度人留下的侧面 - 隔膜A'之外，诱导的所有心脏变化都已完全恢复，除了印度人留下较低。结论：尽管两组肺血流动力学反应相似，但两组之间的心功能参数存在差异响应可能被占种族变异的HA暴露。

Cardiac Acclimatization at High Altitude in Two Different Ethnicity Groups

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