Lignan glycosides from the stems of Viburnum melonocarpum and their α-glucosidase inhibitory activity

Zhao Chunchao; Chen Jia; Shao Jianhua; Shen Jie; Gu Wenyan; Zhang Xiaohui; Sha Yusi

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Lignan glycosides from the stems of Viburnum melonocarpum and their α-glucosidase inhibitory activity

机译：荚Vi荚茎木质素苷及其α-葡萄糖苷酶抑制活性

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Two new lignan glycosides (1, 2) and four known lignan glycosides (3-6) have been isolated from the ethanolic extract of the stems of Viburnum melanocarpum through repeated column chromatography. Their structures including absolute configurations were confirmed by spectroscopic data [one-dimensional (1D) and two-dimensional (2D) nuclear magnetic resonance (NMR), high-resolution electrospray ionization mass spectra (HRESIMS), optical rotatory dispersion (ORD) and circular dichroism (CD)] and chemical methods. Additionally, the alpha-glucosidase inhibitory activity of these compounds was tested in vitro. Compound 1 exhibited the strongest inhibitory activity against alpha-glucosidase with a half-maximal inhibitory concentration (IC50) value of 10.3 mu M.

机译：通过重复柱色谱法从荚果荚the茎的乙醇提取物中分离出两个新的木脂素苷（1、2）和四个已知的木脂素苷（3-6）。它们的结构包括绝对构型已通过光谱数据[一维（1D）和二维（2D）核磁共振（NMR），高分辨率电喷雾电离质谱（HRESIMS），旋光色散（ORD）和圆形证实了二色性（CD）]和化学方法。另外，在体外测试了这些化合物的α-葡萄糖苷酶抑制活性。化合物1对α-葡萄糖苷酶表现出最强的抑制活性，其最大抑制浓度（IC50）值为一半，为10.3μM.

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来源
《Holzforschung》 |2020年第1期|88-93|共6页
作者
Zhao Chunchao; Chen Jia; Shao Jianhua; Shen Jie; Gu Wenyan; Zhang Xiaohui; Sha Yusi;
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作者单位

Yangzhou Univ Coll Biosci & Biotechnol Yangzhou 225009 Jiangsu Peoples R China;

Yangzhou Univ Coll Biosci & Biotechnol Yangzhou 225009 Jiangsu Peoples R China|Yangzhou Univ Jiangsu Key Lab Crop Genet & Physiol Coinnovat Ctr Modern Prod Technol Grain Crops Yangzhou 225009 Jiangsu Peoples R China;

Yangzhou Univ Jiangsu Key Lab Crop Genet & Physiol Coinnovat Ctr Modern Prod Technol Grain Crops Yangzhou 225009 Jiangsu Peoples R China;

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收录信息美国《科学引文索引》(SCI);美国《工程索引》(EI);
原文格式 PDF
正文语种 eng
中图分类
关键词
alpha-glucosidase inhibitory activity; Adoxaceae; lignan glycoside; Viburnum melanocarpum;

机译：α-葡萄糖苷酶抑制活性;豆科;木脂素糖苷;荚荚burn;

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Lignan glycosides from the stems of Viburnum melonocarpum and their α-glucosidase inhibitory activity

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