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Prioritization of Veterinary Medicines in China's Environment

机译：中国环境中的兽药优先

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摘要

Large amounts of veterinary medicines are widely used as therapeutic drugs and feed additives (growth promoters) in China, the environmental presence of which possibly poses challenges to the environment and human health. Therefore, it is important to list the veterinary medicines that are considered to be of relatively high priority in China for environmental management. In this study, a three-stage prioritization scheme was applied to veterinary medicines in China. In Stage Ⅰ, exposure assessment was conducted based on usage amounts and the possibility of entering the environment. In Stage Ⅱ, the ecotoxicity and human health effects of compounds having a high potential to enter the environment were assessed. In Stage III, considering both the results of Stages Ⅰ and Ⅱ, veterinary medicines were assigned into four priority classifications. Using the approach, 38 compounds were assigned to "H," 7 compounds to "M," 2 compounds to "L," and 22 compounds to "VL." Among the top-ranked compounds, antibiotics, endoparasiticides, and aquacultural medicines accounted for 57.9%, 28.9%, and 10.5%, respectively. Insecticides used widely in China's aquaculture need to be taken into account due to their high priority rank. This is the first study on the prioritization of veterinary pharmaceuticals in China.
机译：在中国，大量的兽药被广泛用作治疗药物和饲料添加剂（生长促进剂），其环境存在可能对环境和人类健康构成挑战。因此，重要的是要列出被认为在中国环境管理中具有较高优先级的兽药。在这项研究中，将三阶段优先方案应用于中国的兽药。在第一阶段，根据使用量和进入环境的可能性进行暴露评估。在第二阶段，评估了具有高潜在进入环境的化合物的生态毒性和对人类健康的影响。在第三阶段，考虑到第一阶段和第二阶段的结果，将兽药分为四个优先类别。使用该方法，将38个化合物分配给“ H”，将7个化合物分配给“ M”，将2个化合物分配给“ L”，将22个化合物分配给“ VL”。在排名最高的化合物中，抗生素，内寄生杀虫剂和水产养殖药物分别占57.9％，28.9％和10.5％。由于其优先级高，需要考虑在中国水产养殖中广泛使用的杀虫剂。这是中国对兽药优先排序的第一项研究。

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  • 来源
    《Human and ecological risk assessment》 |2014年第6期|1313-1328|共16页
  • 作者

    Na Wang; Xinyan Guo; Zhengjun Shan; Zanchang Wang; Yi Jin; Shixiang Gao;

  • 作者单位

    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing, China,Nanjing Institute of Environmental Science, Ministry of Environmental Protection of China, Nanjing, China;

    College of Life Science and Technology, China Pharmaceutical University, Nanjing, China;

    Nanjing Institute of Environmental Science, Ministry of Environmental Protection of China, Nanjing, China;

    Nanjing Institute of Environmental Science, Ministry of Environmental Protection of China, Nanjing, China;

    Nanjing Institute of Environmental Science, Ministry of Environmental Protection of China, Nanjing, China;

    State Key Laboratory of Pollution Control and Resource Reuse, School of the Environment, Nanjing University, Nanjing 210093, China;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    prioritization; veterinary medicines; risk; environmental management; China;

    机译：优先次序;兽药;风险;环境管理;中国;

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