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Early Stages of Parkinson's Disease: Comparative Characteristics of Sleep-Wakefulness Cycle in Patients and Model Animals

机译:帕金森氏病的早期阶段:患者和模型动物的睡眠-觉醒周期的比较特征

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摘要

The results of study on the sleep-wakefulness cycle in experimental models of the preclinical and early clinical stages of Parkinson's disease are presented and compared with clinical examples. The conclusion is made that the enhancement of behavioral activity and decrease in the total duration of the slow-wave and paradoxical sleep in model animals occur at the same circadian period of the secretion of pineal melato-nin as sleep disorders in patients.
机译:提出了在帕金森氏病临床前和临床早期实验模型中对睡眠-觉醒周期的研究结果,并与临床实例进行了比较。结论是,模型动物的行为活动增强和慢波和反常睡眠总时间的减少发生在与患者睡眠障碍相同的松果黑素分泌的昼夜节律期间。

著录项

  • 来源
    《Human physiology》 |2015年第6期|667-671|共5页
  • 作者单位

    Severtsov Institute of Ecology and Evolution, Russian Academy of Sciences, Moscow, 119071 Russia;

    Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334 Russia;

    Kol'tsov Institute of Developmental Biology, Russian Academy of Sciences, Moscow, 119334 Russia;

    Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, 117485 Russia;

    Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, 117485 Russia;

    Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, 117485 Russia;

    Institute of Higher Nervous Activity and Neurophysiology, Russian Academy of Sciences, Moscow, 117485 Russia;

    Faculty of Biology, Moscow State University, Moscow, 119992 Russia;

    Sechenov First Moscow State Medical University, Moscow, 119991 Russia;

    Federal Research and Clinical Center of Specialized Medical Care and Medical Technologies, Federal Biomedical Agency, Moscow, 115682 Russia;

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  • 原文格式 PDF
  • 正文语种 eng
  • 中图分类
  • 关键词

    sleep-wakefulness; Parkinson's disease; experimental models;

    机译:觉醒帕金森氏病;实验模型;

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