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Cell Immunity Indices in Crew Members of the Moon-2015 Project

机译:2015年月球成员的细胞免疫指数

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摘要

Cell immunity indices were studied in 6 female participants in the Moon-2015 project at the age of 25 to 34 years. Peripheral blood was analyzed for lymphocyte subtypes CD3_(+), CD3_(+)CD4_(+), CD3_(+)CD8_(+), CD19_(+), and CD3_(–)CD16_(+)CD56_(+)and monocytes and granulocytes that express signal recognition receptors of the Toll-like (TLR) family (TLR2, TLR4, TLR6) localized on the surface of cells. The results of the study have demonstrated a distinct effect of short-term isolation on the immune system ability to mobilize. Rotation on a short-arm centrifuge (SAC) together with a nine-day isolation in a chamber caused diverse responses of the adaptive and innate immune systems. Apparently, the changes observed reflect a complex adaptation process in the innate and acquired immunity at the early stage of adaptation to isolation and also to the exposure to +Gz accelerations (head-to-pelvis) during rotations on SAC.
机译:在25至34岁的月亮2015项目中,在6名女性参与者中研究了细胞免疫指数。分析外周血,用于淋巴细胞亚型CD3 _(+),CD3 _(+)CD4 _(+),CD3 _(+)CD8 _(+),CD19 _(+)和CD3 _( - )CD16 _(+)CD56 _(+)和单核细胞和颗粒细胞,其表达在细胞表面上局部化的Toll样(TLR)族(TLR2,TLR4,TLR6)的信号识别受体。该研究的结果表明了短期隔离对免疫系统动员能力的明显效果。在短臂离心机(SAC)上的旋转以及腔室中的九天隔离导致自适应和先天免疫系统的不同反应。显然,观察到的变化反映了在适应的早期阶段的先天和获得的免疫中的复杂适应过程,并在囊上的旋转期间接触+ GZ加速度(头到骨盆)。

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