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首页> 外文期刊>IEE Proceedings. Nanobiotechnology >Biological applications of localised surface plasmonic phenomenae
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Biological applications of localised surface plasmonic phenomenae

机译：局部表面等离子体现象的生物学应用

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摘要

Researchers and industrialists have taken advantage of the unusual optical, magnetic, electronic, catalytic, and mechanical properties of nanomaterials. Nanoparticles and nanoscale materials have proven to be useful for biological uses. Nanoscale materials hold a particular interest to those in the biological sciences because they are on the same size scale as biological macromolecules, proteins and nucleic acids. The interactions between biomolecules and nanomaterials have formed the basis for a number of applications including detection, biosensing, cellular and in situ hybridisation labelling, cell tagging and sorting, point-of-care diagnostics, kinetic and binding studies, imaging enhancers, and even as potential therapeutic agents. Noble metal nanoparticles are especially interesting because of their unusual optical properties which arise from their ability to support surface plasmons. In this review the authors focus on biological applications and technologies that utilise two types of related plasmonic phenomonae: localised surface plasmon resonance (LSPR) spectroscopy and surface-enhanced Raman spectroscopy (SERS). The background necessary to understand the application of LSPR and SERS to biological problems is presented and illustrative examples of resonant Rayleigh scattering, refractive index sensing, and SERS-based detection and labelling are discussed.
机译：研究人员和工业家已经利用了纳米材料不同寻常的光学，磁性，电子，催化和机械性能。纳米颗粒和纳米级材料已被证明可用于生物用途。纳米材料对生物科学领域特别感兴趣，因为它们与生物大分子，蛋白质和核酸具有相同的规模。生物分子和纳米材料之间的相互作用已成为许多应用的基础，包括检测，生物传感，细胞和原位杂交标记，细胞标记和分类，即时诊断，动力学和结合研究，成像增强剂，甚至是潜在的治疗剂。贵金属纳米粒子之所以特别令人感兴趣，是因为它们具有不寻常的光学特性，这是由于它们能够支撑表面等离子体激元。在这篇综述中，作者集中于利用两种相关等离子体现象的生物学应用和技术：局部表面等离子体共振（LSPR）光谱和表面增强拉曼光谱（SERS）。介绍了理解LSPR和SERS在生物学问题中的应用所必需的背景，并讨论了共振瑞利散射，折射率传感以及基于SERS的检测和标记的示例。

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