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首页> 外文期刊>IEEE/ACM transactions on computational biology and bioinformatics >CGIDLA:Developing the Web Server for CpG Island Related Density and LAUPs (Lineage-Associated Underrepresented Permutations) Study
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CGIDLA:Developing the Web Server for CpG Island Related Density and LAUPs (Lineage-Associated Underrepresented Permutations) Study

机译：Cgidla：开发CPG岛相关密度和Laups的Web服务器（谱系相关的不足排列）研究

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摘要

It is well known that CpG island plays an important role in gene methylation. Since CpG island is closely related to human genetic characteristics such as TATA-box, tissue expression specificity, and LAUPs (Lineage-associated Underrepresented Permutations), it is important to investigate the sequence specificity of CpG island as well as the potential genetic characteristics related to CpG island to further understand the methylation related regulation mechanism. Therefore, this study develops such an online service website for CpG island related density and LAUPs analysis (CGIDLA, www.combio-lezhang.online/cgidla/index.html), that not only can investigate the relationship among the CpG island density, TATA-box feature, and expression breadth of human genes, but also deposit LAUPs of 32 representative species to help molecular biologists investigate the relationship between CpG island and LUAPs. Moreover, CGIDLA provides the source code download service and the related LAUPs counting functions.
机译：众所周知，CPG岛在基因甲基化中起着重要作用。由于CPG岛与塔塔箱，组织表达特异性等人遗传特征密切相关，因此探讨CPG岛的序列特异性以及与之相关的潜在遗传特征是很重要的CPG岛进一步了解甲基化相关的调控机制。因此，本研究开发了用于CPG岛相关密度和Laups分析的在线服务网站（Cgidla，www.combio-lezhang.online/cgidla/index.html），这不仅可以调查CpG岛密度，塔塔之间的关系 - 盒特征，以及人类基因的表达宽度，但也沉积32种代表性物种的劳斯，以帮助分子生物学家调查CpG岛和LAP之间的关系。此外，Cgidla提供源代码下载服务​​和相关的leaps计数功能。

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