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首页> 外文期刊>Computational Biology and Bioinformatics, IEEE/ACM Transactions on >Colored Noise Induced Bistable Switch in the Genetic Toggle Switch Systems
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Colored Noise Induced Bistable Switch in the Genetic Toggle Switch Systems

机译：遗传式拨动开关系统中的有色噪声感应双稳态开关

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摘要

Noise can induce various dynamical behaviors in nonlinear systems. White noise perturbed systems have been extensively investigated during the last decades. In gene networks, experimentally observed extrinsic noise is colored. As an attempt, we investigate the genetic toggle switch systems perturbed by colored extrinsic noise and with kinetic parameters. Compared with white noise perturbed systems, we show there also exists optimal colored noise strength to induce the best stochastic switch behaviors in the single toggle switch, and the best synchronized switching in the networked systems, which demonstrate that noise-induced optimal switch behaviors are widely in existence. Moreover, under a wide range of system parameter regions, we find there exist wider ranges of white and colored noises strengths to induce good switch and synchronization behaviors, respectively; therefore, white noise is beneficial for switch and colored noise is beneficial for population synchronization. Our observations are very robust to extrinsic stimulus strength, cell density, and diffusion rate. Finally, based on the Waddington’s epigenetic landscape and the Wiener-Khintchine theorem, physical mechanisms underlying the observations are interpreted. Our investigations can provide guidelines for experimental design, and have potential clinical implications in gene therapy and synthetic biology.
机译：噪声会在非线性系统中引起各种动力学行为。在过去的几十年中，对白噪声干扰系统进行了广泛的研究。在基因网络中，实验观察到的外部噪声是彩色的。作为一种尝试，我们研究了有色外部噪声和动力学参数干扰的遗传拨动开关系统。与白噪声扰动系统相比，我们表明在单触发开关中还存在最佳的有色噪声强度来诱导最佳的随机开关行为，而在联网系统中，最佳同步开关也存在，这表明噪声引起的最佳开关行为是广泛的。存在。此外，在很宽的系统参数范围内，我们发现存在较大范围的白噪声和有色噪声强度，分别引起良好的开关和同步行为。因此，白噪声有利于开关，彩色噪声有利于总体同步。我们的观察对于外部刺激强度，细胞密度和扩散速率非常有力。最后，根据Waddington的表观遗传情况和Wiener-Khintchine定理，可以解释观测结果的物理机制。我们的研究可以为实验设计提供指导，并在基因治疗和合成生物学方面具有潜在的临床意义。

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