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Fast Entropic Profiler: An InformationTheoretic Approach for the Discovery ofPatterns in Genomes

机译:快速熵探查器:用于发现基因组模式的信息理论方法

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Information theory has been used for quite some time in the area of computational biology. In this paper we present a pattern discovery method, named Fast Entropic Profiler, that is based on a local entropy function that captures the importance of a region with respect to the whole genome. The local entropy function has been introduced by Vinga and Almeida in , here we discuss and improve the original formulation. We provide a linear time and linear space algorithm called Fast Entropic Profiler ($FastEP$), as opposed to the original quadratic implementation. Moreover we propose an alternative normalization that can be also efficiently implemented. We show that $FastEP$ is suitable for large genomes and for the discovery of patterns with unbounded length. $FastEP$ is available at http://www.dei.unipd.it/~ciompin/main/FastEP.html.
机译:信息论已经在计算生物学领域中使用了很长一段时间。在本文中,我们提出了一种名为“快速熵分析器”的模式发现方法,该方法基于局部熵函数,该函数捕获相对于整个基因组而言区域的重要性。 Vinga和Almeida在2000年引入了局部熵函数,在此我们讨论并改进原始公式。与最初的二次实现相反,我们提供了一种称为快速熵分析器($ FastEP $)的线性时间和线性空间算法。此外,我们提出了一种替代的标准化方法,该方法也可以有效实施。我们表明,$ FastEP $适用于大型基因组和无限长度模式的发现。 $ FastEP $可从http://www.dei.unipd.it/~ciompin/main/FastEP.html获得。

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