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首页> 外文期刊>Computational Biology and Bioinformatics, IEEE/ACM Transactions on >Computing Elementary Flux Modes Involving a Set of Target Reactions
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Computing Elementary Flux Modes Involving a Set of Target Reactions

机译：计算涉及一组目标反应的基本通量模式

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摘要

Elementary flux mode (EM) computation is an important tool in the constraint-based analysis of genome-scale metabolic networks. Due to the combinatorial complexity of these networks, as well as the advances in the level of detail to which they can be reconstructed, an exhaustive enumeration of all EMs is often not practical. Therefore, in recent years interest has shifted towards searching EMs with specific properties. We present a novel method that allows computing EMs containing a given set of target reactions. This generalizes previous algorithms where the set of target reactions consists of a single reaction. In the one-reaction case, our method compares favorably to the previous approaches. In addition, we present several applications of our algorithm for computing EMs containing two target reactions in genome-scale metabolic networks. A software tool implementing the algorithms described in this paper is available at .
机译：基本通量模式（EM）计算是基于约束的基因组规模代谢网络分析的重要工具。由于这些网络的组合复杂性以及可对其进行重构的详细程度的提高，所有EM的详尽枚举通常不切实际。因此，近年来，人们的兴趣已转向搜索具有特定属性的EM。我们提出了一种新颖的方法，允许计算包含给定目标反应集的EM。这概括了先前的算法，其中目标反应集由单个反应组成。在单反应情况下，我们的方法比以前的方法优越。此外，我们介绍了我们的算法在计算包含两个目标反应的基因组规模代谢网络中的EM时的几种应用。可在处获得实现本文所述算法的软件工具。

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