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Stability Analysis of the Ribosome Flow Model

机译:核糖体流动模型的稳定性分析

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摘要

Gene translation is a central process in all living organisms. Developing a better understanding of this complex process may have ramifications to almost every biomedical discipline. Recently, Reuveni et al. proposed a new computational model of this process called the ribosome flow model (RFM). In this study, we show that the dynamical behavior of the RFM is relatively simple. There exists a unique equilibrium point e and every trajectory converges to e. Furthermore, convergence is monotone in the sense that the distance to e can never increase. This qualitative behavior is maintained for any feasible set of parameter values, suggesting that the RFM is highly robust. Our analysis is based on a contraction principle and the theory of monotone dynamical systems. These analysis tools may prove useful in studying other properties of the RFM as well as additional intracellular biological processes.
机译:基因翻译是所有活生物体的核心过程。对这个复杂的过程有更好的了解可能会对几乎每个生物医学学科产生影响。最近,Reuveni等。提出了这一过程的新计算模型,称为核糖体流动模型(RFM)。在这项研究中,我们表明RFM的动力学行为相对简单。存在一个唯一的平衡点e,并且每个轨迹都收敛到e。而且,从到e的距离永远不会增加的意义上说,收敛是单调的。对于任何可行的参数值集,都保留了这种定性行为,这表明RFM具有很高的鲁棒性。我们的分析基于收缩原理和单调动力系统理论。这些分析工具可能对研究RFM的其他属性以及其他细胞内生物学过程很有用。

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