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首页> 外文期刊>Selected Topics in Quantum Electronics, IEEE Journal of >Medical Uses of Fluorescence Imaging: Bringing Disease to Light
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Medical Uses of Fluorescence Imaging: Bringing Disease to Light

机译：荧光成像的医学用途：将疾病曝光

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摘要

Fluorescence imaging is becoming an important diagnostic method in medicine. Advances in the quantum yields and properties of fluorophores combined with better biologic targeting make fluorescence imaging attractive. The lack of ionizing radiation, the lower costs, and the portability of optical imaging are additional advantages. Traditional fluorescence imaging probes are “always on” and require rapid biologic clearance of the unbound probe to achieve adequate target-to-background ratios. More advanced fluorescence imaging probes are “activatable,” meaning that they become fluorescent only under particular circumstances, such as after binding to the cell. This creates opportunities for very high target-to-background ratios, thus dramatically increasing sensitivity. When fluorescent probes also cause phototoxicity, they become both therapeutic and diagnostic (theranostic) agents and enable a “see and treat” paradigms. Here, we discuss the evolution of novel diagnostic probes in our laboratory ending with the development of targeted theranostic probes.
机译：荧光成像正在成为医学中重要的诊断方法。荧光团的量子产率和性质的进步与更好的生物靶向相结合，使荧光成像具有吸引力。缺少电离辐射，较低的成本以及光学成像的便携性是其他优势。传统的荧光成像探针是“永远在线”的，并且需要对未结合的探针进行快速的生物清除，以实现足够的靶与背景之比。更高级的荧光成像探针是“可激活的”，这意味着它们仅在特定情况下（例如与细胞结合后）才发出荧光。这为极高的目标背景比创造了机会，从而大大提高了灵敏度。当荧光探针也引起光毒性时，它们既可以成为治疗剂，也可以成为诊断剂（热疗剂），并实现了“看即治疗”的范例。在这里，我们讨论了新型诊断探针在实验室中的发展，并最终发展了靶向治疗探针。

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