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Optical Fiber Ring Cavity Sensor for Label-Free DNA Detection

机译：用于无标记DNA检测的光纤环形腔传感器

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摘要

An outcladding sensitized label-free DNA biosensor is developed based on tilted fiber Bragg gratings. The biosensor, functionalized with peptide nucleic acid (PNA) probes, is based on a double tilted fiber Bragg grating that forms a modified Fabry–Perot core-cladding closed-loop cavity. Interference is set up between an injected guided mode and the reflected core mode and cladding modes created by the light scattered by the tilted gratings, leading to the generation of interference fringes within both these spectral notches. When the DNA binds to the PNA probes attached onto the fiber cladding, a refractive index change occurs at the cladding–PNA interface and the fringe visibility changes accordingly. Real-time spectral measurement results are reported, showing that a 10-nM DNA solution induces a 10% modulation of the corresponding fringes visibility. Cycling tests are performed for measuring and checking the repeatability of the sensor.
机译：基于倾斜的光纤布拉格光栅，开发了一种外层敏化的无标记DNA生物传感器。该生物传感器采用肽核酸（PNA）探针进行功能化，基于双倾斜光纤布拉格光栅，该光栅形成了改良的Fabry-Perot芯-包层闭环腔。在由倾斜光栅散射的光所产生的注入引导模式与反射纤芯模式和包层模式之间会建立干涉，从而导致在这两个光谱陷波内产生干涉条纹。当DNA与附着在光纤包层上的PNA探针结合时，折射率在包层-PNA界面处发生变化，并且条纹的可见性也随之变化。报告了实时光谱测量结果，显示10nM DNA溶液可诱导相应条纹可见度的10％调制。执行循环测试以测量和检查传感器的可重复性。

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