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Single-Particle Cryo-Electron Microscopy: Mathematical Theory, Computational Challenges, and Opportunities

机译:单粒子冷冻电子显微镜:数学理论,计算挑战和机遇

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摘要

In recent years, an abundance of new molecular structures have been elucidated using cryo-electron microscopy (cryo-EM), largely due to advances in hardware technology and data processing techniques. Owing to these exciting new developments, cryo-EM was selected by Nature Methods as the "Method of the Year 2015," and the Nobel Prize in Chemistry 2017 was awarded to three pioneers in the cryo-EM field: Jacques Dubochet, Joachim Frank, and Richard Henderson "for developing cryoelectron microscopy for the high-resolution structure determination of biomolecules in solution" [93].
机译:近年来,使用冷冻电子显微镜(Cryo-EM)阐明了丰富的新分子结构,主要是由于硬件技术和数据处理技术的进步。由于这些令人兴奋的新发展,Cryo-Em被自然方法选择,作为“2015年的方法”,2017年化学诺贝尔奖颁发给Cryo-Em领域的三个先驱:Jacques Dubochet,Joachim Frank,和Richard Henderson“用于开发冷冻电子显微镜,用于溶液中的生物分子的高分辨率结构测定”[93]。

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