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首页> 外文期刊>IEEE transactions on biomedical circuits and systems >A 65-nm CMOS Fully Integrated Analysis Platform Using an On-Chip Vector Network Analyzer and a Transmission-Line-Based Detection Window for Analyzing Circulating Tumor Cell and Exosome
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A 65-nm CMOS Fully Integrated Analysis Platform Using an On-Chip Vector Network Analyzer and a Transmission-Line-Based Detection Window for Analyzing Circulating Tumor Cell and Exosome

机译：使用片上矢量网络分析仪和基于传输线的检测窗口的65nm CMOS完全集成的分析平台，用于分析循环肿瘤细胞和外来

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摘要

A fully integrated CMOS circuit based on a vector network analyzer and a transmission-line-based detection window for circulating tumor cell (CTC) and exosome analysis is presented for the first time. We have introduced a fully integrated architecture, which eliminates the undesired parasitic components and enables high-sensitivity, to analyze extremely low-concentration CTC in blood. The detection window was designed on the high-sensitive coplanar waveguide line. To validate the operation of the proposed system, a test chip was fabricated using 65-nm CMOS technology. Measurements were performed after adding a tiny lump of silicone or a droplet of water on its detection window. The measured results show vertical bar S_21 vertical bar degradation of -1.96 dB and -6.04 dB for the silicone and the droplet, respectively, at 1.4 GHz. In addition, in another measurement using magnetic beads, it is confirmed that the proposed circuit can analyze even low concentrations of 20 beads/mu L. As well as microbeads, measurement with CTCs was successfully demonstrated.
机译：基于矢量网络分析仪的完全集成的CMOS电路和用于循环肿瘤细胞（CTC）和外出分析的基于传输线的检测窗口。我们引入了一种完全集成的架构，可消除不需要的寄生成分并实现高灵敏度，分析血液中极低浓度的CTC。在高敏感的共面波导线上设计了检测窗口。为了验证所提出的系统的操作，使用65nm CMOS技术制造测试芯片。在其检测窗口中加入微小的硅氧烷或水滴后进行测量。测量结果显示垂直条S_21垂直条劣化-1.96dB和-6.04 dB，分别为1.4 GHz。另外，在使用磁珠的另一个测量中，确认所提出的电路可以分析甚至低浓度的20珠/μl。以及微珠，用CTCS的测量成功证明。

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