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首页> 外文期刊>IEEE transactions on biomedical circuits and systems >Closed-Loop Neurostimulators: A Survey and A Seizure-Predicting Design Example for Intractable Epilepsy Treatment
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Closed-Loop Neurostimulators: A Survey and A Seizure-Predicting Design Example for Intractable Epilepsy Treatment

机译:闭环神经刺激器:顽固性癫痫治疗的调查和癫痫发作预测设计实例

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摘要

First, existing commercially available open-loop and closed-loop implantable neurostimulators are reviewed and compared in terms of their targeted application, physical size, system-level features, and performance as a medical device. Next, signal processing algorithms as the primary strength point of the closed-loop neurostimulators are reviewed, and various design and implementation requirements and trade-offs are discussed in details along with quantitative examples. The review results in a set of guidelines for algorithm selection and evaluation. Second, the implementation of an inductively-powered seizure-predicting microsystem for monitoring and treatment of intractable epilepsy is presented. The miniaturized system is comprised of two miniboards and a power receiver coil. The first board hosts a 24-channel neurostimulator system on chip [15] fabricated in a 0.13 μm CMOS technology and performs neural recording, on-chip digital signal processing, and electrical stimulation. The second board communicates recorded brain signals as well as signal processing results wirelessly. The multilayer flexible coil receives inductively-transmitted power. The system is sized at 2 × 2 × 0.7 cm and weighs 6 g. The approach is validated in the control of chronic seizures in vivo in freely moving rats.
机译:首先,对现有的市售开环和闭环植入式神经刺激器进行了审查,并根据它们的目标应用,物理尺寸,系统级功能以及作为医疗设备的性能进行了比较。接下来,回顾作为闭环神经刺激器主要优势的信号处理算法,并详细讨论各种设计和实现要求以及权衡取舍以及定量示例。审查得出了一组算法选择和评估指南。其次,介绍了用于监测和治疗难治性癫痫的感应动力癫痫预测微系统的实现。小型化系统由两个微型板和一个受电线圈组成。第一板在0.13μmCMOS技术中制造了一个片上24通道神经刺激器系统[15],并执行神经记录,片上数字信号处理和电刺激。第二块板以无线方式传输记录的大脑信号以及信号处理结果。多层柔性线圈接收感应传输的功率。该系统的大小为2×2×0.7厘米,重6克。该方法已在自由活动大鼠体内控制慢性癫痫发作中得到验证。

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