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首页> 外文期刊>Biomedical Circuits and Systems, IEEE Transactions on >CMOS Conductometric System for Growth Monitoring and Sensing of Bacteria
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CMOS Conductometric System for Growth Monitoring and Sensing of Bacteria

机译：用于细菌生长监测和传感的CMOS电导系统

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摘要

We present the design and implementation of a prototype complementary metal–oxide semiconductor (CMOS) conductometric integrated circuit (IC) for colony growth monitoring and specific sensing of Escherichia coli (E. coli) bacteria. The detection of E. coli is done by employing T4 bacteriophages as receptor organisms. The conductometric system operates by measuring the resistance of the test sample between the electrodes of a two-electrode electrochemical system (reference electrode and working electrode). The CMOS IC is fabricated in a TSMC 0.35-$mu$m process and uses a current-to-frequency (I to F) conversion circuit to convert the test sample resistance into a digital output modulated in frequency. Pulsewidth control (one-shot circuit) is implemented on-chip to control the pulsewidth of the output digital signal. The novelty in the current work lies in the ability of the CMOS sensor system to monitor very low initial concentrations of bacteria ($4times 10^{2}$ to $4times 10^{4}$ colony forming unit (CFU)/mL). The CMOS system is also used to record the interaction between E. coli and its specific receptor T4 bacteriophage. The prototype CMOS IC consumes an average power of 1.85 mW with a 3.3-V dc power supply.
机译：我们介绍了用于菌落生长监测和大肠杆菌（E. coli）细菌特异性感测的原型互补金属氧化物半导体（CMOS）电导集成电路（IC）的设计和实现。大肠杆菌的检测是通过使用T4噬菌体作为受体生物来完成的。电导系统通过测量两电极电化学系统的电极（参考电极和工作电极）之间的测试样品电阻来进行操作。 CMOS IC以TSMC0.35-μm工艺制造，并使用电流至频率（I至F）转换电路将测试样本电阻转换为频率调制的数字输出。脉冲宽度控制（单脉冲电路）在芯片​​上实现，以控制输出数字信号的脉冲宽度。当前工作的新颖之处在于CMOS传感器系统能够监测极低的细菌初始浓度（4倍10 ^ {2} $到4倍10 ^ {4} $菌落形成单位（CFU）/ mL） 。 CMOS系统还用于记录大肠杆菌与其特异性受体T4噬菌体之间的相互作用。原型CMOS IC在3.3V直流电源下的平均功耗为1.85 mW。

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