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首页> 外文期刊>IEEE transactions on biomedical circuits and systems >A Real-Time Multi-Channel Monitoring System for Stem Cell Culture Process
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A Real-Time Multi-Channel Monitoring System for Stem Cell Culture Process

机译：干细胞培养过程的实时多通道监测系统

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摘要

A novel, up to 128 channels, multi-parametric physiological measurement system suitable for monitoring hematopoietic stem cell culture processes and cell cultures in general is presented in this paper. The system aims to measure in real-time the most important physical and chemical culture parameters of hematopoietic stem cells, including physicochemical parameters, nutrients, and metabolites, in a long-term culture process. The overarching scope of this research effort is to control and optimize the whole bioprocess by means of the acquisition of real-time quantitative physiological information from the culture. The system is designed in a modular manner. Each hardware module can operate as an independent gain programmable, level shift adjustable, 16 channel data acquisition system specific to a sensor type. Up to eight such data acquisition modules can be combined and connected to the host PC to realize the whole system hardware. The control of data acquisition and the subsequent management of data is performed by the system''s software which is coded in LabVIEW. Preliminary experimental results presented here show that the system not only has the ability to interface to various types of sensors allowing the monitoring of different types of culture parameters. Moreover, it can capture dynamic variations of culture parameters by means of real-time multi-channel measurements thus providing additional information on both temporal and spatial profiles of these parameters within a bioreactor. The system is by no means constrained in the hematopoietic stem cell culture field only. It is suitable for cell growth monitoring applications in general.
机译：本文提出了一种新颖的，多达128个通道的多参数生理测量系统，适用于监测造血干细胞的培养过程和一般的细胞培养。该系统旨在在长期培养过程中实时测量造血干细胞最重要的物理和化学培养参数，包括理化参数，营养物质和代谢产物。这项研究工作的总体范围是通过从培养物中获取实时定量生理信息来控制和优化整个生物过程。该系统以模块化方式设计。每个硬件模块均可作为特定于传感器类型的独立增益可编程，电平移位可调的16通道数据采集系统运行。最多可以组合八个这样的数据采集模块并将其连接到主机PC，以实现整个系统硬件。数据采集​​的控制和随后的数据管理是由用LabVIEW编码的系统软件执行的。此处提供的初步实验结果表明，该系统不仅具有与各种类型的传感器接口的能力，还可以监视不同类型的培养参数。此外，它可以通过实时多通道测量来捕获培养参数的动态变化，从而提供有关生物反应器中这些参数的时间和空间分布的附加信息。该系统绝不仅限于造血干细胞培养领域。通常，它适用于细胞生长监测应用。

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