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首页> 外文期刊>Magnetics, IEEE Transactions on >Design and Analysis of Novel Focused Hyperthermia Devices
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Design and Analysis of Novel Focused Hyperthermia Devices

机译：新型聚焦热疗仪的设计与分析

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摘要

Magnetic fluid hyperthermia (MFH) is a promising cancer therapy by virtue of its good depth penetration. As the injected magnetic fluids of MFH are inevitably distributed in the tumor as well as in normal tissues nearby, it is difficult to accurately heat and ablate the targeted tumor without damaging the surrounding healthy tissues. Based on the observation that magnetic nanoparticles are only heated by alternating fields and not by static dc fields, it is possible to exploit such findings in MFH therapy to provide an efficient cure for cancer patients. To avoid unnecessary heating of healthy tissues, a novel system is proposed to set up a dc magnetic field around the tumor target. At the same time, the system creates a field-free region (FFR) with negligible static magnetic field in the target area. The target area can then be fully heated by an alternating field whereas the nearby tissues are not heated. In this paper, a novel ac and dc magnetic field combined MFH system, targeting the treatment area, is presented to produce an accurately focused magnetic field to abate the tumor cells. The proposed method is validated using finite element analysis.
机译：磁流体热疗（MFH）凭借其良好的深度渗透性而成为一种有前途的癌症治疗方法。由于注射的MFH磁流体不可避免地分布在肿瘤以及附近的正常组织中，因此难以在不损坏周围健康组织的情况下准确加热和消融目标肿瘤。基于观察到磁性纳米颗粒仅由交变场而不是由静态dc场加热，可以在MFH治疗中利用这些发现为癌症患者提供有效的治疗方法。为了避免对健康组织的不必要加热，提出了一种新颖的系统来在肿瘤靶标周围建立直流磁场。同时，系统会在目标区域中创建具有可忽略不计的静磁场的无磁场区域（FFR）。然后，目标区域可以被交变场完全加热，而附近的组织没有被加热。在本文中，提出了针对治疗区域的新型交流和直流磁场组合式MFH系统，以产生精确聚焦的磁场来减轻肿瘤细胞。有限元分析验证了该方法的有效性。

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