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首页> 外文期刊>IEEE Transactions on Magnetics >Characterizing a Preclinical Magnetic Particle Imaging System With Separate Pickup Coil
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Characterizing a Preclinical Magnetic Particle Imaging System With Separate Pickup Coil

机译：用独立的拾取线圈表征临床前磁性粒子成像系统

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摘要

Magnetic particle imaging (MPI) is an emerging technology with the potential for great impact on both medicine and biomedical research. Its optimization and acceptance are dependent upon a significant research effort in the development of tracer materials, data acquisition equipment, and image reconstruction techniques. We present initial results obtained from a prototype signal acquisition instrument designed to offer improvements to the sensitivity, and signal-to-noise ratio (SNR), of a preclinical MPI system (Bruker 25/20). We present the Fourier analysis of the signals detected using both the original data collection instrument provided with the MPI system, and the new prototype detector. By comparison of the spectra obtained, we show that the imaging signals from the prototype instrument are of greater intensity, and extend into higher frequencies, than those obtained using the original measurement instrument. We present image reconstructions of vascular phantoms containing tracer at concentrations between c(Fe) = 0.1 and 0.0125 mol/L. The improved sensitivity of the prototype detector allows the resolution of phantoms at tracer concentrations below those attainable using the original detector instrument. Finally, we quantify the improvement offered by the new detector based on a summation of the SNR values above a background threshold, within the frequency region of interest for MPI data acquisition. By plotting these totals at a variety of sample concentrations, we calculate a final receive gain (FRG) factor to describe the improvement offered by the new detector. For the prototype studied, we find FRG = 4.7 ± 0.6.
机译：磁粉成像（MPI）是一项新兴技术，具有对医学和生物医学研究产生巨大影响的潜力。它的优化和可接受性取决于在示踪材料，数据采集设备和图像重建技术方面的大量研究工作。我们介绍了从原型信号采集仪器获得的初步结果，该仪器旨在改善临床前MPI系统（Bruker 25/20）的灵敏度和信噪比（SNR）。我们介绍了使用MPI系统随附的原始数据收集仪器和新的原型检测器对检测到的信号进行傅立叶分析。通过比较所获得的光谱，我们显示，与使用原始测量仪器获得的信号相比，来自原型仪器的成像信号具有更高的强度，并延伸到更高的频率。我们提出了在c（Fe）= 0.1和0.0125 mol / L之间浓度的含示踪剂的血管幻影的图像重建。原型探测器的灵敏度提高了，因此在示踪剂浓度以下的幻像分辨率低于使用原始探测器仪器可获得的幻像。最后，我们在MPI数据采集的目标频率区域内，基于高于背景阈值的SNR值之和，量化了新检测器提供的改进。通过在各种样品浓度下绘制这些总数，我们计算出最终接收增益（FRG）因子，以描述新检测器提供的改进。对于所研究的原型，我们发现FRG = 4.7±0.6。

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