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首页> 外文期刊>IEEE Transactions on Radiation and Plasma Medical Sciences >Evaluation of a Sub-Millimeter Resolution PET Detector With a 1.2 mm Pitch TSV-MPPC Array One-to-One Coupled to LFS Scintillator Crystals and Inter-Crystal Scatter Studies With Individual Signal Readout
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Evaluation of a Sub-Millimeter Resolution PET Detector With a 1.2 mm Pitch TSV-MPPC Array One-to-One Coupled to LFS Scintillator Crystals and Inter-Crystal Scatter Studies With Individual Signal Readout

机译：1.2毫米间距TSV-MPPC阵列与LFS闪烁体晶体一对一耦合的亚毫米分辨率PET检测器的评估以及具有单个信号读出的晶体间散射研究

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摘要

To develop a small animal positron emission tomography (PET) scanner for whole body imaging of mice, a sub-millimeter resolution PET detector has been constructed and its performance evaluated. This PET detector is composed of a 1.2 mm pitch multi-pixel photon counter (MPPC) 8 × 8 array with through-silicon via (TSV) structure one-to-one coupled to Lutetium Fine Silicate (LFS) scintillator crystals of size 1.13 mm × 1.13 mm × 10 mm each. To evaluate the intrinsic spatial resolution and the energy resolution in coincidence events, the coincidence response functions (CRFs) of the detector pair, located facing each other at a distance of 80 mm, were measured by scanning a 0.25 mm diameter Na point source in 0.1 mm steps. The data were acquired by the computer automated measurement and control (CAMAC) system. The average full width at half maximum (FWHM) of the CRFs was 0.75 mm without point source size corrections. The average FWHM of the energy resolution was 16% at 511 keV. The coincidence timing resolution (CTR) was also evaluated by facing the detector and a fast photomultiplier tube (PMT) coupled with a BaF crystal. The expected average FWHM of the CTR between the detectors was 770 ps. Additionally, to improve detector efficiency while suppressing the positioning errors, we propose an interaction-order scheme based on Compton kinematics and adapt it to the same data. We also perform Monte Carlo simulations using GEANT4 10.01 to evaluate the accuracy of the proposed positioning scheme and compare it to that of a centroid calculation scheme. As a result, we demonstrate that the accuracy of the proposed positioning scheme is better than that of a centroid calculation scheme when inter-crystal scatter events occur.
机译：为了开发用于小鼠全身成像的小型动物正电子发射断层扫描（PET）扫描仪，已构建了亚毫米分辨率的PET检测器，并对其性能进行了评估。该PET检测器由1.2毫米间距的多像素光子计数器（MPPC）8×8阵列和一对硅通孔（TSV）结构一对一耦合到尺寸为1.13毫米的硅酸Fine玻璃（LFS）闪烁体晶体组成×1.13毫米×10毫米为了评估重合事件中的固有空间分辨率和能量分辨率，通过在0.1 mm的距离内扫描0.25 mm直径的Na点源来测量彼此相对的探测器对的重合响应函数（CRF），相距80 mm毫米级。数据通过计算机自动测量和控制（CAMAC）系统获取。 CRF的半峰平均全宽（FWHM）为0.75毫米，未进行点源尺寸校正。能量分辨率的平均FWHM在511 keV时为16％。还通过面向检测器和与BaF晶体耦合的快速光电倍增管（PMT）来评估重合定时分辨率（CTR）。检测器之间的CTR的预期平均FWHM为770 ps。另外，为了在抑制定位误差的同时提高检测器效率，我们提出了一种基于康普顿运动学的交互顺序方案，并将其适应于相同的数据。我们还使用GEANT4 10.01执行蒙特卡洛模拟，以评估所提出的定位方案的准确性，并将其与质心计算方案的准确性进行比较。结果，我们证明了当晶体间散射事件发生时，所提出的定位方案的精度优于质心计算方案。

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