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Ultrafast Radial Modulation Imaging

机译:超快径向调制成像

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摘要

Radial modulation imaging improves the detection of microbubbles at high frequency using a dual ultrasonic excitation. However, the synchronization between the imaging pulses is nontrivial because microbubbles need to be interrogated in the compression and the rarefaction phase, and the time-delay difference from dispersion has to be corrected. To address these issues, we propose the use of ultrafast radial modulation imaging (uRMI). In this technique, a beat frequency between the modulation pulse (around 1 MHz) and the ultrafast pulse-repetition frequency was exploited to separate microbubbles from tissue phantom in vitro. This led to a modulated images' set in the spectral domain of the slow time that may then be demodulated through a digital lock-in amplifier to retrieve the contrast image. Ultrafast RMI, applied on a flow phantom with microbubbles, provided a contrast-to-tissue ratio from 7.2 to 14.8 dB at 15 MHz. For flow speed lower than 0.05 mL/min, uRMI (16 dB) provided a better contrast-to-tissue ratio than other techniques: singular value decomposition spatiotemporal filter (11 dB), amplitude modulation (9 dB), or microbubbles disruption (6 dB). This technique may then be suitable to improve the detection of targeted microbubbles, in ultrasound molecular imaging applications, and the detection of extremely slow microbubbles moving in the finest vessels in ultrasound localization microscopy.
机译:径向调制成像使用双重超声波激励改善了高频微气泡的检测。然而,由于在压缩和稀疏阶段需要询问微泡,并且必须校正来自色散的时间延迟差,因此成像脉冲之间的同步是不平凡的。为了解决这些问题,我们建议使用超快径向调制成像(uRMI)。在这项技术中,利用调制脉冲(大约1 MHz)和超快脉冲重复频率之间的拍频在体外将微气泡从组织体模中分离出来。这导致在慢时间的频谱域中设置了调制图像,然后可以通过数字锁定放大器对其进行解调以获取对比度图像。应用于带有微气泡的流动体模上的超快RMI,在15 MHz时提供了7.2至14.8 dB的对比度/组织比率。对于低于0.05 mL / min的流速,uRMI(16 dB)提供了比其他技术更好的对比度/组织比率:奇异值分解时空滤波器(11 dB),幅度调制(9 dB)或微气泡破坏(6 D b)。然后,该技术可能适合于在超声分子成像应用中改进对目标微气泡的检测,以及在超声定位显微镜中检测在最细血管中移动的极慢微气泡的检测。

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