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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >Feasibility and Validation of 4-D Pulse Wave Imaging in Phantoms and In Vivo
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Feasibility and Validation of 4-D Pulse Wave Imaging in Phantoms and In Vivo

机译：幻影和体内4D脉搏波成像的可行性和验证

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摘要

Pulse wave imaging (PWI) is a noninvasive technique for tracking the propagation of the pulse wave along the arterial wall. The 3-D ultrasound imaging would aid in objectively estimating the pulse wave velocity (PWV) vector. This paper aims to introduce a novel PWV estimation method along the propagation direction, validate it in phantoms, and test its feasibility in vivo. A silicone vessel phantom consisting of a stiff and a soft segment along the longitudinal axis and a silicone vessel with a plaque were constructed. A 2-D array with a center frequency of 2.5 MHz was used. Propagation was successfully visualized in 3-D in each phantom and in vivo in six healthy subjects. In three of the healthy subjects, results were compared against conventional PWI using a linear array. PWVs were estimated in the stiff (3.42 ± 0.23 m · s) and soft (2.41 ± 0.07 m · s) phantom segments. Good agreement was found with the corresponding static testing values (stiff: 3.41 m · s and soft: 2.48 m · s). PWI-derived vessel compliance values were validated with dynamic testing. Comprehensive views of pulse propagation in the plaque phantom were generated and compared against conventional PWI acquisitions. Good agreement was found in vivo between the results of 4-D PWI (4.80 ± 1.32 m · s) and conventional PWI (4.28 ± 1.20 m · s) (n = 3). PWVs derived for all of the healthy subjects (n = 6) were within the physiological range. Thus, the 4-D PWI was successfully validated in phantoms and used to image the pulse wave propagation in normal human subjects in vivo.
机译：脉搏波成像（PWI）是一种用于跟踪脉搏波沿动脉壁传播的非侵入性技术。 3-D超声成像将有助于客观地估计脉搏波速度（PWV）向量。本文旨在介绍一种新的沿传播方向的PWV估计方法，在体模中对其进行验证，并在体内测试其可行性。构造了由沿着纵向轴线的刚性段和柔软段组成的硅树脂容器模型和具有斑块的硅树脂容器。使用中心频率为2.5 MHz的二维阵列。在6个健康受试者的每个体模中和体内，成功地以3-D方式查看了传播情况。在三个健康受试者中，使用线性阵列将结果与常规PWI进行了比较。在刚性（3.42±0.23 m·s）和软（2.41±0.07 m·s）幻像段中估计PWV。与相应的静态测试值（刚度：3.41 m·s和软度：2.48 m·s）发现吻合良好。通过动态测试验证了PWI得出的血管顺应性值。产生了斑块体模中脉冲传播的综合视图，并将其与常规PWI采集进行了比较。在体内4-D PWI（4.80±1.32 m·s）和常规PWI（4.28±1.20 m·s）（n = 3）的结果之间存在良好的一致性。为所有健康受试者（n = 6）获得的PWV在生理范围内。因此，在人体模型中成功地验证了4-D PWI，并将其用于成像脉搏波在体内正常人体内的传播。

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