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首页> 外文期刊>Ultrasonics, Ferroelectrics and Frequency Control, IEEE Transactions on >Cranial nerve threshold for thermal injury induced by MRI-guided high-intensity focused ultrasound (MRgHIFU): preliminary results on an optic nerve model
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Cranial nerve threshold for thermal injury induced by MRI-guided high-intensity focused ultrasound (MRgHIFU): preliminary results on an optic nerve model

机译：MRI引导的高强度聚焦超声（MRgHIFU）引起的颅脑热损伤阈值：视神经模型的初步结果

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摘要

Future clinical applications of magnetic resonance imaging-guided high-intensity focused ultrasound (MRgHIFU) are moving toward the management of different intracranial pathologies. We sought to validate the production, safety, and efficacy of thermal injury to cranial nerves generated by MRgHIFU. In this study, five female domestic pigs underwent a standard bifrontal craniectomy under general anesthesia. Treatment was then given using an MRgHIFU system to induce hyperthermic ablative sonication (6 to 10 s; 50 to 2000 J.) Histological analyses were done to confirm nerve damage; temperature measured on the optic nerve was approximately 53.4u000b0;C (range: 39u000b0;C to 70u000b0;C.) Histology demonstrated a clear definition between a necrotic, transitional zone, and normal tissue. MRgHIFU induces targeted thermal injury to nervous tissue within a specific threshold of 50u000b0;C to 60u000b0;C with the tissue near the sonication center yielding the greatest effect; adjacent tissue showed minimal changes. Additional studies utilizing this technology are required to further establish accurate threshold parameters for optic nerve thermo-ablation.
机译：磁共振成像引导的高强度聚焦超声（MRgHIFU）的未来临床应用正在朝着不同颅内病变的管理方向发展。我们试图验证MRgHIFU产生的颅神经热损伤的生产，安全性和功效。在这项研究中，五只雌性家猪在全身麻醉下进行了标准的双额颅骨颅骨切除术。然后使用MRgHIFU系统进行治疗，以诱导高温消融性超声（6至10 s； 50至2000J。）。在视神经上测得的温度约为53.4u000b0; C（范围：39u000b0; C至70u000b0; C。）组织学显示坏死，过渡区和正常组织之间有明确的定义。 MRgHIFU在50u000b0; C至60u000b0; C的特定阈值范围内对神经组织产生针对性的热损伤，超声中心附近的组织产生最大的作用；邻近组织无明显变化。需要进一步利用这项技术进行研究，以进一步建立用于视神经热消融的准确阈值参数。

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