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首页> 外文期刊>Ultrasonics, Ferroelectrics and Frequency Control, IEEE Transactions on >In vitro comminution of model renal calculi using histotripsy
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In vitro comminution of model renal calculi using histotripsy

机译：组织碎裂术在体外粉碎模型肾结石

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Shock wave lithotripsy (SWL) suffers from the fact that it can produce residual stone fragments of significant size (>2 mm). Mechanistically, cavitation has been shown to play an important role in the reduction of such fragments to smaller debris. In this study, we assessed the feasibility of using cavitationally-based pulsed ultrasound therapy (histotripsy) to erode kidney stones. Previous work has shown that histotripsy is capable of mechanically fractionating soft tissue into fine, acellular debris. Here, we investigated the potential for translating this technology to renal calculi through the use of a commonly accepted stone model. Stone models were sonicated using a 1-MHz focused transducer, with 5-cycle pulses delivered at a rate of 1 kHz. Pulses having peak negative pressures ranging from 3 to 21 MPa were tested. Results indicate that histotripsy is capable of effectively eroding the stone model, achieving an average stone erosion rate of 26 mg/min at maximum treatment pressure; substantial stone erosion was only observed in the presence of a dense cavitational bubble cloud. Sequential sieving of residual stone fragments indicated that debris produced by histotripsy was smaller than 100 ;C;m in size, and treatment monitoring showed that both the cavitational bubble cloud and model stone appear as hyperechoic regions on B-mode imaging. These preliminary results indicate that histotripsy shows promise in its use for stone comminution, and an optimized erosion process may provide a potential adjunct to conventional SWL procedures.
机译：冲击波碎石术（SWL）遭受这样的事实，即它会产生残留的巨大碎石碎片（> 2 mm）。从机械上讲，空化已显示在将此类碎片减少为较小碎片中起重要作用。在这项研究中，我们评估了使用基于空化的脉冲超声疗法（组织碎裂）侵蚀肾结石的可行性。以前的工作表明，组织曲折能够将软组织机械分离成细小的无细胞碎片。在这里，我们研究了通过使用公认的结石模型将该技术转化为肾结石的潜力。使用1 MHz聚焦换能器对石材模型进行超声处理，并以1 kHz的速率传递5个周期的脉冲。测试了峰值负压范围为3到21 MPa的脉冲。结果表明，组织分裂症能够有效侵蚀石材模型，在最大治疗压力下平均石材侵蚀速率为26 mg / min。仅在浓空化气泡云的存在下才观察到大量石材侵蚀。残留的碎石块的顺序筛分表明，组织碎屑产生的碎屑小于100 C; m，治疗监测表明，空泡云和模型结石在B型成像中均表现为高回声区域。这些初步结果表明，组织碎裂术在将其用于石块粉碎方面显示出前景，并且最佳的腐蚀过程可能为常规的SWL程序提供潜在的辅助手段。

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