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首页> 外文期刊>Ultrasonics, Ferroelectrics and Frequency Control, IEEE Transactions on >In vitro and in vivo brain ablation created by high-intensity focused ultrasound and monitored by MRI
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In vitro and in vivo brain ablation created by high-intensity focused ultrasound and monitored by MRI

机译：高强度聚焦超声在体外和体内大脑消融中的作用，并通过MRI进行监测

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In this paper, magnetic resonance imaging (MRI) is investigated for monitoring small and large lesions created by high-intensity focused ultrasound (HIFU) in freshly excised lamb brain and in rabbit brain in vivo. A single-element spherically focused transducer of 5 cm diameter, focusing at 10 cm and operating at 1 MHz was used. A prototype MRI-compatible positioning device that is used to navigate the transducer is described. The effects of HIFU were investigated using T1-W and T2-W fast spin echo (FSE) and fluid-attenuated inversion recovery (FLAIR). T2-W FSE and FLAIR show better anatomical details within the brain than T1-W FSE, but with T1-W FSE, the contrast between lesion and brain is higher for both thermal and bubbly lesions. The best contrast between lesion and brain with T1-W FSE is obtained with TR above 500 ms, whereas with T2-W FSE, the best contrast is observed between 40 and 60 ms. The maximum contrast to noise ratio (CNR) measured with T1-W FSE was approximately 20. With T2-W FSE, the corresponding CNR was approximately 12. With this system, we were able to create large lesions (by producing overlapping lesions), and it was possible to monitor these lesions with MRI with excellent contrast. The length of the lesions in vivo brain was much higher than the length in vitro, indicating that the penetration in the in vitro brain is limited, possibly by reflection due to trapped bubbles in the blood vessels. This paper demonstrates that HIFU has the potential to treat brain tumors in humans. This could be done either using a single-element transducer with a frequency around 1 MHZ or using a multi-element transducer.
机译：在本文中，研究了磁共振成像（MRI）来监测新鲜切除的羔羊脑和兔脑中高强度聚焦超声（HIFU）产生的大小病变。使用直径为5 cm，聚焦在10 cm且工作频率为1 MHz的单元件球形聚焦换能器。描述了用于导航换能器的原型MRI兼容定位设备。使用T1-W和T2-W快速自旋回波（FSE）和流体衰减反转恢复（FLAIR）研究了HIFU的效果。与T1-W FSE相比，T2-W FSE和FLAIR在大脑中显示出更好的解剖学细节，但是对于T1-W FSE，对于热性和起泡性病变，病变和大脑之间的对比度更高。 T1-W FSE在500 ms以上时可获得病灶与大脑之间的最佳对比，而T2-W FSE在40至60 ms之间可观察到最佳对比。使用T1-W FSE测得的最大对比度与噪声比（CNR）约为20。使用T2-W FSE时，相应的CNR约为12。使用该系统，我们能够创建大的病变（通过产生重叠的病变），并可以通过MRI以优异的对比度监测这些病变。体内脑部病变的长度远高于体外脑部的长度，这表明体外脑部的渗透受到限制，这可能是由于血管中夹有气泡引起的反射。本文证明HIFU具有治疗人类脑瘤的潜力。可以使用频率约为1 MHZ的单元素换能器或使用多元素换能器来完成。

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