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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >Microcirculation volumetric flow assessment using high-resolution, contrast-assisted images
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Microcirculation volumetric flow assessment using high-resolution, contrast-assisted images

机译：使用高分辨率，对比辅助图像进行微循环容积流量评估

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摘要

To improve the resolution of contrast-assisted imaging systems, we previously developed a 25-MHz microbubbles-destruction/replenishment imaging system with a spatial resolution of 160 X 160 mum. The goal of the present study was to propose a new approach for functionally evaluating the microvascular volumetric blood flow based on this high-frequency, ultrasound imaging system. The approach includes locating the perfusion area and estimating the blood flow velocity therein. Because the correlation changes between before and after microbubble destruction in two adjacent images, a correlated-based approach was introduced to detect the blood perfusion area. We also have derived a new sigmoid-based model for characterizing the microbubbles replenishment process. Two parameters derived from the sigmoid-based model - the rate constant and inflection time - were adopted to evaluate the blood flow velocity. This model was validated using both simulations and in vitro experiments for mean flow velocities ranging from 1 to 10 mm/s, which showed that the model was in good agreement with simulated and measured microbubble-replenishment time-intensity curves. The results indicate that the actual flow velocity is highly correlated with the estimates of the rate constant and the reciprocal of the inflection time. B-mode imaging experiments for mean flow velocities ranging from 0.4 to 2.1 mm/s were used to assess the volumetric flow in the microcirculation. The results indicated the high correlation between the actual volumetric flow rate and the product of the estimated perfusion area and rate constant, and the reciprocal of the inflection time. We also found that the boundary of the microbubble destruction volume significantly affected estimations of the flow velocity. The perfusion area can be located, and the corresponding flow velocity can be estimated simultaneously in a one-stage, microbubble-destruction/replenishment process, which makes the assessment of the volumetric bloo-d flow in the microcirculation feasible using a real-time, high-frequency ultrasound system.
机译：为了提高对比度辅助成像系统的分辨率，我们先前开发了空间分辨率为160 X 160 mum的25 MHz微气泡破坏/补给成像系统。本研究的目的是提出一种基于该高频超声成像系统的功能性评估微血管体积血流的新方法。该方法包括定位灌注区域并估计其中的血流速度。由于在两个相邻图像中破坏微泡之前和之后之间的相关性发生变化，因此引入了一种基于相关性的方法来检测血液灌注区域。我们还派生了一个新的基于S形的模型，用于表征微气泡的补给过程。采用基于S形模型的两个参数-速率常数和拐点时间-来评估血流速度。通过仿真和体外实验验证了该模型的平均流速范围为1至10 mm / s，这表明该模型与模拟和测量的微气泡补给时间-强度曲线非常吻合。结果表明，实际流速与速率常数的估计值和拐点时间的倒数高度相关。 B模式成像实验的平均流速范围为0.4至2.1 mm / s，用于评估微循环中的体积流量。结果表明，实际体积流量与估计的灌注面积和速率常数的乘积与拐点时间的倒数之间具有高度相关性。我们还发现，微泡破坏体积的边界会显着影响流速的估计。可以在一个阶段的微气泡破坏/补充过程中定位灌注区域，并同时估算相应的流速，这使得使用实时实时评估微循环中的体积血流成为可能，高频超声系统。

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