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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >High Speed Imaging of Bubble Clouds Generated in Pulsed Ultrasound Cavitational Therapy - Histotripsy
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High Speed Imaging of Bubble Clouds Generated in Pulsed Ultrasound Cavitational Therapy - Histotripsy

机译：脉冲超声空化疗法中产生的气泡云的高速成像-组织学

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Our recent studies have demonstrated that mechanical fractionation of tissue structure with sharply demarcated boundaries can be achieved using short (< 20 mus), high intensity ultrasound pulses delivered at low duty cycles. We have called this technique histotripsy. Histotripsy has potential clinical applications where noninvasive tissue fractionation and/or tissue removal are desired. The primary mechanism of histotripsy is thought to be acoustic cavitation, which is supported by a temporally changing acoustic backscatter observed during the histotripsy process. In this paper, a fast-gated digital camera was used to image the hypothesized cavitating bubble cloud generated by histotripsy pulses. The bubble cloud was produced at a tissue-water interface and inside an optically transparent gelatin phantom which mimics bulk tissue. The imaging shows the following: 1) Initiation of a temporally changing acoustic backscatter was due to the formation of a bubble cloud; 2) The pressure threshold to generate a bubble cloud was lower at a tissue-fluid interface than inside bulk tissue; and 3) at higher pulse pressure, the bubble cloud lasted longer and grew larger. The results add further support to the hypothesis that the histotripsy process is due to a cavitating bubble cloud and may provide insight into the sharp boundaries of histotripsy lesions.
机译：我们最近的研究表明，在低占空比下使用短（<20 mus），高强度超声脉冲可以实现具有清晰划界的组织结构的机械分离。我们称这种技术为组织学。在需要非侵入性组织分级分离和/或组织去除的情况下，组织变性具有潜在的临床应用。人们认为组织学的主要机制是声空化，这是由在组织学过程中观察到的随时间变化的声反向散射所支持的。在本文中，使用了快速门控数码相机对由组织变性脉冲产生的假设的空化气泡云进行成像。气泡云是在组织与水的界面处以及模仿大块组织的光学透明明胶模型内部产生的。成像显示以下内容：1）随时间变化的声学反向散射的产生是由于气泡云的形成； 2）在组织-流体界面处产生气泡云的压力阈值低于在大块组织内部； 3）在较高的脉冲压力下，气泡云持续时间更长，并且变得更大。该结果进一步支持了以下事实的假设，即：组织学过程是由于空化的气泡云造成的，并且可以提供对组织学病变的尖锐边界的洞察力。

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