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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >Transducer design for a portable ultrasound enhanced transdermal drug-delivery system
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Transducer design for a portable ultrasound enhanced transdermal drug-delivery system

机译：便携式超声增强型透皮给药系统的换能器设计

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摘要

For application in a portable transdermal drug-delivery system, novel transducers have been designed to enhance insulin transmission across skin using ultrasound. Previous research has shown transdermal delivery of insulin across skin using commercial sonicators operating at 20 kHz with intensities ranging from 12.5 to 225 mW/cm2. The goal of this research was to design and construct a small, lightweight transducer or array that could operate with a similar frequency and intensity range as a commercial sonicator used in previous transdermal ultrasound insulin experiments, but without the weight and mass of a sonicator probe. To obtain this intensity range, a cymbal transducer design was chosen because of its light, compact structure and low resonance frequency in water. To increase the spatial ultrasound field for drug delivery across skin, two arrays, each comprising of four cymbal transducers, were constructed. The first array, designated the standard array, used four cymbals transducer elements in parallel. A second array (named the stack array) used four cymbal transducers that used stacked piezoelectric discs to drive the titanium flextensional caps. Under similar driving conditions, the standard array produced intensities comparable to those achieved using a commercial sonicator.
机译：为了在便携式透皮药物传递系统中应用，已经设计了新颖的换能器，以使用超声波增强胰岛素在皮肤上的传输。先前的研究表明，使用商业超声仪以20 kHz的频率在12.5至225 mW / cm2的强度范围内经皮肤透皮输送胰岛素。这项研究的目的是设计和构建一个小型，轻便的换能器或阵列，其工作频率和强度范围可以与以前的经皮超声胰岛素实验中使用的商用超声仪相似，但没有超声仪探头的重量和质量。为了获得此强度范围，选择了transducer换能器设计，因为它轻巧，结构紧凑且在水中的共振频率低。为了增加空间超声场以跨皮肤递送药物，构建了两个阵列，每个阵列包括四个c换能器。第一个阵列，称为标准阵列，使用了四个平行的换能器元件。第二个阵列（称为堆叠阵列）使用四个c换能器，这些换能器使用堆叠的压电圆盘来驱动钛合金抗拉盖。在相似的驱动条件下，标准阵列产生的强度可与使用商用超声仪获得的强度相媲美。

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