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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >Development and characterization of a vitreous mimicking material for radiation force imaging
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Development and characterization of a vitreous mimicking material for radiation force imaging

机译：用于辐射力成像的玻璃态模拟材料的开发和表征

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In many medical ultrasound applications tissue-mimicking phantoms are of fundamental importance for the performance of controlled experiments. Traditionally, such phantoms have been constructed using gelatin and agar gels. Although the use of these materials has become standard, few alternative materials have not been fully explored. In this paper, we present a protocol developed in our laboratory that reliably produces very soft, acrylamide-based phantoms that can mimic both acoustical and mechanical characteristics of the vitreous body of the eye. Following the described protocol, a series of phantoms were constructed ranging in acrylamide concentration from 1.60% to 1.70%. Measurements across the series yielded attenuation coefficients of 0.067-0.140 dB/cm/MHz, depending on acrylamide concentration. Speed of sound ranged between 1499 and 1510 m/s, also depending on acrylamide concentration. Published values for the vitreous gel indicate an attenuation of 0.10 dB/cm/MHz and a speed of sound of 1510 m/s, making our phantoms an excellent analog of this tissue. One application of these acrylamide phantoms is to test the efficacy of the Kinetic Acoustic Vitreoretinal Examination (KAVE), a tool developed in our laboratory with the potential to aid in the diagnosis of vitreoretinal disorders. KAVE utilizes acoustic radiation force to generate small, localized displacements within the vitreous-mimicking gel. These localized displacements are quantified to yield maximum displacement, relative elasticity, and relative viscosity images. We present KAVE images of a set of four phantoms with different gel concentrations. Although B-mode and relative viscosity images exhibit no significant differences, maximum displacement, and relative elasticity images clearly differentiate gels of different concentrations. Maximum displacements ranged between 30 and 5 microns, depending on acrylamide concentration. The results presented in this paper show that soft gel phantoms can be produced in a range of elasticities not previously reported, and that these phantoms are useful for testing ultrasound instruments designed for evaluation of the vitreous gel. Furthermore, the use of acrylamide-based gels may also offer a valuable and attractive alternative for many other ultrasound applications.
机译：在许多医学超声应用中，模仿组织的体模对于进行受控实验至关重要。传统上，已经使用明胶和琼脂凝胶构建了这种幻影。尽管这些材料的使用已成为标准，但很少有替代材料尚未得到充分探索。在本文中，我们介绍了在实验室中开发的协议，该协议可以可靠地生成非常柔软的基于丙烯酰胺的幻像，该幻像可以模仿眼睛玻璃体的声学和机械特性。按照所描述的方案，构建一系列幻影，其丙烯酰胺浓度范围为1.60％至1.70％。整个系列的测量得出的衰减系数为0.067-0.140 dB / cm / MHz，具体取决于丙烯酰胺的浓度。声速在1499至1510 m / s之间，这也取决于丙烯酰胺的浓度。玻璃凝胶的公布值表明衰减为0.10 dB / cm / MHz，声速为1510 m / s，这使我们的幻影成为该组织的极佳模拟物。这些丙烯酰胺体模的一种应用是测试动态声学玻璃体视网膜检查（KAVE）的功效，该技术是我们实验室开发的有潜力帮助诊断玻璃体视网膜疾病的工具。 KAVE利用声辐射力在模仿玻璃体的凝胶内产生小的局部位移。量化这些局部位移以产生最大位移，相对弹性和相对粘度图像。我们展示了具有不同凝胶浓度的四个体模的KAVE图像。尽管B模式和相对粘度图像没有显示出显着差异，但是最大位移和相对弹性图像可以清楚地区分不同浓度的凝胶。最大位移范围在30到5微米之间，具体取决于丙烯酰胺的浓度。本文介绍的结果表明，可以在以前没有报道的范围内产生软凝胶体模，并且这些体模可用于测试设计用于评估玻璃体凝胶的超声仪器。此外，基于丙烯酰胺的凝胶的使用还可为许多其他超声应用提供有价值且有吸引力的替代方法。

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