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Characterization of reperfused infarcted myocardium from high-frequency intracardiac ultrasound imaging using homodyned K distribution

机译:使用匀浆K分布从高频心内超声成像重新灌注心肌梗死的特征

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Myocardial changes caused by infarction/reperfusion (contraction band necrosis, hemorrhage, edema, etc.) may result in an increased scatterer density and a variation in scatterer arrangement. This paper, for the first time, models most of the scattering conditions resulting from the interaction of ultrasound and normal/reperfused infarcted myocardium using the homodyned K distribution. Furthermore, this method is used to characterize the change in scatterer density by calculating the effective scatterer number per resolution cell. The reliability and the effects of attenuation and scan conversion on effective scatterer number estimation are discussed. We used in vivo data acquired using high-frequency intracardiac ultrasound imaging (8.5 MHz) from the left and right ventricles of open-chest pigs in an acute infarction/reperfusion model. The results show that the homodyned K distribution describes the statistical distribution of backscattered signal from both normal and abnormal myocardium. A significant increase in scatterer density occurs in the infarcted region after reperfusion compared with the same region at baseline (normal myocardium prior to occlusion). The scatterer density of the normal region does not change significantly after reperfusion. We conclude that the homodyned K distribution may characterize normal and reperfused infarcted myocardium using high-frequency intracardiac ultrasound images.
机译:由梗塞/再灌注引起的心肌变化(收缩带坏死,出血,水肿等)可能导致散射体密度增加和散射体排列变化。本文首次使用均质K分布模型模拟了超声和正常/再灌注梗死心肌相互作用所产生的大多数散射条件。此外,此方法用于通过计算每个分辨率像元的有效散射体数量来表征散射体密度的变化。讨论了可靠性和衰减以及扫描转换对有效散射体数量估计的影响。在急性梗塞/再灌注模型中,我们使用了通过高频心内超声成像(8.5 MHz)从开胸猪的左右心室获得的体内数据。结果表明,同质化的K分布描述了正常和异常心肌后向散射信号的统计分布。与基线时的同一区域(闭塞前的正常心肌)相比,再灌注后的梗塞区域散射物密度显着增加。正常区域的散射密度在再灌注后没有显着变化。我们得出的结论是,使用高频心内超声图像,均质K分布可表征正常和再灌注的梗塞心肌。

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