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Ultrasonic beam focusing through tissue inhomogeneities with a timereversal mirror: application to transskull therapy

机译:带有计时器倒影镜的超声束聚焦通过组织不均匀性:在经颅治疗中的应用

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摘要

Time reversal of ultrasonic fields allows a very efficientnapproach to focus pulsed ultrasonic waves through lossless inhomogeneousnmedia. Time reversal mirrors (TRMs) are made of large transducer arrays,nallowing the incident field to be sampled, time reversed, and reemitted.nTime reversal method corrects for phase, amplitude, and even shapenaberration and thus, is more efficient than time shift compensationntechniques. However, this technique needs the knowledge of the Green'snfunction of a dominant scatterer available in the medium. Aberrationncorrection for ultrasonic hyperthermia could be achieved by combiningnTRM with an artificial acoustic source or sensor implanted inside thentreatment volume. In this paper, time reversal method has beennexperimentally applied to the focusing through the skull bone. It isnshown that the skull induces severe attenuation of ultrasound andnreduces the efficiency of the time reversal approach. Then, an amplitudencorrection method is proposed to focus through an attenuating layernlocated close to the array. This method consists in inversing thenamplitude modulation and then time reversing these signals. Finally,nthis method is combined with numerical backpropagation to compensate fornan attenuating layer located some distance away from the transducernarray
机译:超声场的时间反转允许非常有效的方法通过无损非均匀介质聚焦脉冲超声波。时间倒转镜(TRM)由大型换能器阵列制成,允许对入射场进行采样,时间倒转和重新发射。n时间倒转方法可校正相位,幅度甚至形状畸变,因此比时移补偿技术更有效。但是,此技术需要了解介质中可用的主要散射体的格林函数。超声热疗的像差校正可以通过将nTRM与植入治疗空间内的人工声源或传感器结合使用来实现。在本文中,时间逆转方法已被实验性地应用于通过颅骨的聚焦。没有显示出颅骨会引起超声波的严重衰减并降低时间倒转方法的效率。然后,提出了一种振幅校正方法,以聚焦通过位于靠近阵列的衰减层。该方法包括反转幅度调制,然后时间反转这些信号。最后,将该方法与数值反向传播相结合,以补偿距换能器阵列一定距离的纳米衰减层

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