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Semiautomatic Estimation of Device Size for Left Atrial Appendage Occlusion in 3-D TEE Images

机译:3-D T恤图像中左心房阑尾闭塞装置尺寸的半自动估计

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摘要

Left atrial appendage (LAA) occlusion is used to reduce the risk of thromboembolism in patients with non-valvular atrial fibrillation by obstructing the LAA through a percutaneously delivered device. Nonetheless, correct device sizing is complex, requiring the manual estimation of different measurements in preprocedural/periprocedural images, which is tedious and time-consuming and with high interobserver and intraobserver variability. In this paper, a semiautomatic solution to estimate the required relevant clinical measurements is described. This solution starts with the 3-D segmentation of the LAA in 3-D transesophageal echocardiographic images, using a constant blind-ended model initialized through a manually defined spline. Then, the segmented LAA surface is aligned with a set of templates, i.e., 3-D surfaces plus relevant measurement planes (manually defined by one observer), transferring the latter to the unknown situation. Specifically, the alignment is performed in three consecutive steps, namely: 1) rigid alignment using the LAA clipping plane position; 2) orientation compensation using the circumflex artery location; and 3) anatomical refinement through a weighted iterative closest point algorithm. The novel solution was evaluated in a clinical database with 20 volumetric TEE images. Two experiments were set up to assess: 1) the sensitivity of the model's parameters and 2) the accuracy of the proposed solution for the estimation of the clinical measurements. Measurement levels manually identified by two observers were used as ground truth. The proposed solution obtained results comparable to the interobserver variability, presenting narrower limits of agreement for all measurements. Moreover, this solution proved to be fast, taking nearly 40 s (manual analysis took 3 min) to estimate the relevant measurements while being robust to the variation of the model's parameters. Overall, the proposed solution showed its potential for fast and robust estimation of the clinical measurements for occluding device selection, proving its added value for clinical practice.
机译:左心房附属物(LAA)闭塞用于通过通过经皮递送的装置阻塞LAA来降低非瓣膜心房颤动患者血栓栓塞的风险。尽管如此,正确的器件尺寸是复杂的,需要在预兴板/围页图像中手动估计不同测量的,这是繁琐且耗时的,并且具有高的Interobserver和intraobserver变异性。本文描述了一种估计所需相关临床测量的半自动溶液。该解决方案以3-D TranseSophagehocarGographic图像中的LAA的3-D分段开始,使用通过手动定义的样条初始化的恒定的盲目模型。然后,分段的LAA表面与一组模板对齐,即3-D表面加上相关测量平面(手动定义),将后者转移到未知情况。具体地,对准在三个连续步骤中执行,即:1)使用LAA夹平面位置的刚性对准; 2)使用恒定动脉位置的定向补偿; 3)通过加权迭代最近点算法解剖学改进。在具有20个容量T恤图像的临床数据库中评估新的解决方案。建立了两个实验,评估了:1)模型参数的灵敏度和2)所提出的解决方案的准确性,用于估计临床测量。两个观察者手动识别的测量水平被用作地面真理。所提出的解决方案获得了与Interobserver变异相当的结果,呈现了所有测量的较窄的协议限制。此外,该解决方案证明是快速的,采用近40秒(手动分析3分钟)来估计相关测量,同时对模型参数的变化稳健。总的来说,所提出的解决方案表明其对闭塞装置选择的临床测量的快速和鲁棒估计的潜力,证明了其临床实践的附加值。

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    Katholieke Univ Leuven Dept Cardiovasc Sci Lab Cardiovasc Imaging & Dynam B-3000 Leuven Belgium|Univ Minho Sch Med Life & Hlth Sci Res Inst ICVS P-4710057 Braga Portugal|Univ Minho ICVS 3Bs PT Govt Associate Lab P-4710057 Braga Portugal|Univ Porto Inst Ciencia & Inovacao Engn Mecan & Engn Ind Fac Engn Dept Engn Mecan P-4150177 Porto Portugal|2Ai Polytech Inst Cavado & Ave P-4750810 Barcelos Portugal;

    Univ Minho ICVS 3Bs PT Govt Associate Lab P-4710057 Braga Portugal|2Ai Polytech Inst Cavado & Ave P-4750810 Barcelos Portugal|Univ Minho Life & Hlth Sci Res Inst P-4710057 Braga Portugal;

    Katholieke Univ Leuven Dept Cardiovasc Sci Lab Cardiovasc Imaging & Dynam B-3000 Leuven Belgium|Univ Minho ICVS 3Bs PT Govt Associate Lab P-4710057 Braga Portugal|Univ Minho Life & Hlth Sci Res Inst P-4710057 Braga Portugal|Univ Minho Algoritmi Ctr P-4800058 Guimaraes Portugal;

    Univ Hosp Leuven Dept Cardiol B-3000 Leuven Belgium;

    Univ Hosp Leuven Dept Cardiol B-3000 Leuven Belgium;

    Univ Porto Inst Ciencia & Inovacao Engn Mecan & Engn Ind Fac Engn Dept Engn Mecan P-4150177 Porto Portugal;

    Katholieke Univ Leuven Dept Cardiovasc Sci Lab Cardiovasc Imaging & Dynam B-3000 Leuven Belgium;

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  • 正文语种 eng
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  • 关键词

    3-D image segmentation; 3-D transesophageal echocardiography; iterative closest point; left atrial appendage (LAA) occlusion; semiautomatic occluding device sizing;

    机译:3-D图像分割;3-D经细胞深呼超声造影;迭代最接近点;左心房附属物(LAA)闭塞;半自动闭塞装置尺寸;

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