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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >3-D X-Ray-Induced Acoustic Computed Tomography With a Spherical Array: A Simulation Study on Bone Imaging
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3-D X-Ray-Induced Acoustic Computed Tomography With a Spherical Array: A Simulation Study on Bone Imaging

机译：3-D X射线引起的声学计算断层扫描与球形阵列：骨成像模拟研究

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摘要

X-ray-induced acoustic computed tomography (XACT) is a promising imaging modality combining high X-ray absorption contrast with the 3-D propagation advantages provided by high-resolution ultrasound waves. The purpose of this study was to optimize the configuration of a 3-D XACT imaging system for bone imaging. A 280 ultrasonic sensorswith peak frequency of 10MHz was designed to distribute on a spherical surface to optimize the 3-D volumetric imaging capability. We performed both theoretical calculations and simulations of this optimized XACT imaging configuration on a mouse-sized digital phantom containing various X-ray absorption coefficients. Iteration algorithm based on total variation has been used for 3-D XACT image reconstruction. The spatial resolution of imaging was estimated to about 130 mu m along both axial and lateral directions. We simulate XACT imaging of bone microstructures using digital phantoms generated from micro-CT images of real biological samples, showing that XACT imaging can provide high-resolution imaging of the mouse paw. Results of this study will greatly enhance the potential of XACT imaging in the evaluation of bone diseases for future clinical use.
机译：X射线诱导的声学计算机断层扫描（XACT）是与高分辨率超声波提供的3-D传播优点相结合的高X射线吸收对比的有希望的成像模型。本研究的目的是优化用于骨成像的3-D XACT成像系统的配置。为10MHz的峰值频率的280超声波传感器设计用于在球面上分布，以优化3-D体积成像能力。我们在包含各种X射线吸收系数的鼠标大小的数字幻像上进行了理论计算和模拟这种优化的XACT成像配置。基于总变化的迭代算法已用于三维XACT图像重建。沿轴向和横向估计成像的空间分辨率估计为约130μm。我们使用从真实生物样品的微型CT图像产生的数码模拟骨微观结构的XACT成像，表明XACT成像可以提供鼠标爪的高分辨率成像。该研究的结果将大大提高XACT成像在对未来临床用途评估骨病中的潜力。

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