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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >Photoacoustic Impulse Response of Lipid-Coated Ultrasound Contrast Agents
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Photoacoustic Impulse Response of Lipid-Coated Ultrasound Contrast Agents

机译：脂质涂层超声造影剂的光声脉冲响应

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摘要

The utility of ultrasound imaging and therapy with microbubbles may be greatly enhanced by determining their impulse-response dynamics as a function of size and composition. Prior methods for microbubble characterization utilizing high-speed cameras, acoustic transducers and laser-based techniques typically scan a limited frequency range. Here, we report on the use of a novel photoacoustic technique to measure the impulse response of single microbubbles. Individual microbubbles are driven with a broadband photoacoustic wave generated by a nanosecond-pulse laser illuminating an optical absorber. The resulting microbubble oscillations were detected by following transmission of a second laser as it passes twice through the microbubble. The system could even resolve oscillations resulting from a single-shot. As a proof-of-concept study, the size-dependent, linear impulse response of lipid-coated microbubbles was characterized using this technique. This unique method of microbubble characterization with exceptional spatiotemporal resolution opens new avenues for capturing and analyzing microbubble system dynamics.
机译：通过确定其脉冲响应动态作为尺寸和组成的函数，可以大大提高超声成像和治疗的效用。利用高速摄像机的微胶质表征的现有方法，声学换能器和基于激光的技术通常扫描有限频率范围。在这里，我们报告使用一种新颖的光声技术来测量单微泡的脉冲响应。用由纳秒脉冲激光照射光学吸收器的纳秒脉冲激光器产生的宽带光声波驱动各个微泡。通过在通过微泡通过两次通过微泡来检测所得到的微泡振荡检测到第二激光器。系统甚至可以解决由单次引起的振荡。作为概念证据，使用该技术表征了初级依赖性微泡的线性脉冲响应。这种微泡特性具有特殊时空分辨率的独特方法，可打开新的途径，用于捕获和分析微泡系统动态。

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