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首页> 外文期刊>IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control >High-Frequency Array-Based Nanobubble Nonlinear Imaging in a Phantom and In Vivo
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High-Frequency Array-Based Nanobubble Nonlinear Imaging in a Phantom and In Vivo

机译：基于高频阵列的纳米粗纳米粗脉模在幻影和体内

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摘要

There has been growing interest in nanobubbles (NBs) for vascular and extravascular ultrasound contrast imaging and therapeutic applications. Studies to date have generally utilized low frequencies (<12 MHz), high concentrations (>10(9) mL(-1)), and uncalibrated B-mode or contrast-mode on commercial systems without reporting investigations on NB signatures upon which the imaging protocols should be based. We recently demonstrated that low concentrations (10(6) mL(-1)) of porphyrin-lipid-encapsulated NBs scatter nonlinearly at low (2.5, 8 MHz) and high (12.5, 25, 30 MHz) frequencies in a pressure threshold-dependent manner that is advantageous for amplitude modulation (AM) imaging. Here, we implement pressure-calibrated AM at high frequency on a commercial preclinical array system to enhance sensitivity to nonlinear scattering of three phospholipid-based NB formulations. With this approach, improvements in contrast to tissue ratio relative to B-mode between 12.4 and 22.8 dB are demonstrated in a tissue-mimicking phantom, and between 6.7 and 14.8 dB in vivo.
机译：对血管和血管外超声对比度成像和治疗应用的纳米博布尔（NBS）产生了兴趣。迄今为止的研究通常使用低频率（<12MHz），高浓度（> 10（9）毫升（-1））和商业系统上的未校准B模式或对比模式，而不报告对NB签名的调查成像协议应该是基于的。我们最近证明，低浓度（10（6）毫升（-1））的卟啉 - 脂质包封的NBS在压力阈值下在低（2.5,8MHz）和高（12.5,25,30MHz）频率下非线性地散射 - 依赖性的方式是有利的幅度调制（AM）成像。这里，我们在商业临床前阵列系统上以高频实施压力校准的AM，以增强三种基于磷脂基Nb制剂的非线性散射的敏感性。利用这种方法，在组织 - 模拟体内和体内在6.7和14.8dB之间对与12.4和22.8dB之间相对于B模式的组织比对比的改善。

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