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首页> 外文期刊>Indian Journal of Pediatrics >Epidemiology and pathophysiology of Helicobacter pylori infection in children
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Epidemiology and pathophysiology of Helicobacter pylori infection in children

机译：儿童幽门螺杆菌感染的流行病学和病理生理学

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摘要

Helicobacter pylori is one of the commonest bacterial pathogens in human. The organism is associated with development of peptic ulcer diseases, lymphoproliferative disorders and gastric cancer. Residence in a developing country, poor socioeconomic conditions and genetic predisposition are regarded as risk factors. Prevalence of infection is higher in developing countries and re-infection is higher among under five children. It is transmitted mainly through feco-oral route in developing countries and gastro-oral route in developed nations. Transmission of close-contact infection depends on the degree of mixing and age-distribution between susceptible and infected individuals. Host and bacterial factors with interaction of environment contribute pathogenicity. H. pylori cytotoxin-associated geneA (cagA), vacuolating toxinA (vacA) and adherence factors to gastric epithelium have been linked to enhanced pathogenicity of the bacterium. Host genetic polymorphism of cytokines, related legends, receptors and enzymes influence H. pylori infection.
机译：幽门螺杆菌是人类最常见的细菌病原体之一。该生物体与消化性溃疡疾病，淋巴增生性疾病和胃癌的发展有关。居住在发展中国家，不良的社会经济条件和遗传易感性被认为是危险因素。发展中国家的感染率较高，五岁以下儿童的再感染率较高。它主要通过发展中国家的口经途径和发达国家的胃口途径传播。紧密接触感染的传播取决于易感人群和感染人群之间的混合程度和年龄分布。宿主和细菌因素与环境的相互作用造成了致病性。幽门螺杆菌细胞毒素相关基因A（cagA），空泡毒素A（vacA）和胃上皮粘附因子与细菌致病性增强有关。细胞因子的宿主遗传多态性，相关的图例，受体和酶影响幽门螺杆菌感染。

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